نتایج جستجو برای: oxygen glucose deprivation

تعداد نتایج: 408420  

Journal: :Biophysical journal 2013
Sotiris Psilodimitrakopoulos Valerie Petegnief Nuria de Vera Oscar Hernandez David Artigas Anna M Planas Pablo Loza-Alvarez

Neuronal death can be preceded by progressive dysfunction of axons. Several pathological conditions such as ischemia can disrupt the neuronal cytoskeleton. Microtubules are basic structural components of the neuronal cytoskeleton that regulate axonal transport and neuronal function. Up-to-date, high-resolution observation of microtubules in living neuronal cells is usually accomplished using fl...

2015
Catherine I. Rousset Fiona C. Leiper Anton Kichev Pierre Gressens David Carling Henrik Hagberg Claire Thornton

Perinatal hypoxic-ischaemic encephalopathy (HIE) occurs in 1-2 in every 1000 term infants and the devastating consequences range from cerebral palsy, epilepsy and neurological deficit to death. Cellular damage post insult occurs after a delay and is mediated by a secondary neural energy failure. AMP-activated protein kinase (AMPK) is a sensor of cellular stress resulting from ATP depletion and/...

2017
Bo Zhang Yunfeng Yang Jun Tang Yihao Tao Bing Jiang Zhi Chen Hua Feng Liming Yang Gang Zhu

OBJECTIVE The objective of this study is to establish a co-culture model of mouse neurons and microglial cells, and to analyze the mechanism of action of oxygen glucose deprivation (OGD) and transient oxygen glucose deprivation (tOGD) preconditioning cell models. RESULTS Mouse primary neurons and BV2 microglial cells were successfully cultured, and the OGD and tOGD models were also establishe...

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