The aim of the present study was to evaluate the underlying processes involved in the oxygen wasting induced by inotropic drugs and acute and chronic elevation of fatty acid (FA) supply, using unloaded perfused mouse hearts from normal and type 2 diabetic (db/db) mice. We found that an acute elevation of the FA supply in normal hearts, as well as a chronic (in vivo) exposure to elevated FA as i...

SYNOPSIS. TWO processes strongly influence the distribution of oxygen within egg masses and cells: the supply of oxygen by diffusion and the consumption of oxygen by embryos and mitochondria. These processes are differentially sensitive to temperature. The diffusion coefficient of oxygen depends only weakly on temperature, having a Ql0 of approximately 1.4. In contrast, the consumption of oxyge...

We developed a computational model to predict oxygen levels in microfluidic plastic devices during cell culture. This model is based on experimental evaluation of oxygen levels. Conditions are determined that provide adequate oxygen supply to two cell types, hepatocytes and endothelial cells, either by diffusion through the plastic device, or by supplying a low flow rate of medium.

BACKGROUND It is well established that physical training enhances functionality and quality of life in patients with COPD. However, little data exist concerning the effects of the usefulness of oxygen supply during exercise training for > 3 months in patients with COPD who are normoxemic at rest and during exercise. We hypothesized that oxygen supply during training sessions enables higher trai...

A fall in oxygen tension of the inspired air demands that both circulatory and respiratory adjustments be made if the tissues are to receive an adequate supply of oxygen. Increase in ventilation will reduce the oxygen tension difference between the air breathed and the arterial blood, but even so when the oxygen tension of the arterial blood (PB> 0 | ) falls a decrease in oxygen supply to the t...

Background: The Brain uses 20% of the total oxygen supply consumed by the entire body. Even though, <10% of the brain is active at any given time, it utilizes almost all the oxygen delivered. In order to perform complex tasks or more than one task (multitasking), the oxygen supply is shifted from one brain region to another, via blood perfusion modulation. The aim of the present study was to ev...

In ecology, strategy schemes based on propositions about the selection of plant attributes are common, but quantification of such schemes in relation to nutrient and water supply is lacking. Through structural equation modeling, we tested whether plant strategies related to nutrient and water/oxygen supply are reflected in a coordination of traits in natural communities. Structural equation mod...

Sleep disordered breathing (SDB) is a frequent finding in the elderly. SDB is related to morbidity, mortality, quality of life, disability, and cognitive impairment. Treatment of choice for SDB is nasal positive airway pressure breathing (nCPAP). The impact of treatment for SDB on activities of daily living (ADLs) is unclear. We therefore investigated the relationship between SDB and ADLs in a ...