BACKGROUND We wanted to assess whether there was a significant relationship between recruited lung volume (V(rec)) and change in density on digital processed chest x-ray measured at 2 different levels of inspiratory plateau pressure corresponding to 2 PEEP levels in patients with acute lung injury or ARDS. METHODS In 14 subjects, PEEP 5 cm H2O and 15 cm H2O were prospectively applied in a ran...

The imprinted gene PLAGL1 is an important regulator of apoptosis and cell cycle arrest. Loss of its expression has been implicated in tumorigenesis in a range of different cancers, and overexpression during fetal development causes transient neonatal diabetes mellitus (TNDM). PLAGL1 lies within an imprinted region of chromosome 6q24, and monoallelic expression from the major, differentially met...

An activity, RNase E, was purified about 100-fold from Escherichia coli cells, it can process p5 rRNA from a 9 S RNA molecule which accumulates in a mutant of E. coli defective in the maturation of 5 S rRNA. The enzyme requires Na+, K+, or NH4+, and Mg2+ or Mn2+. The molecular weight of the enzyme is about 70,000 and its pH optimum is 7.6 to 8.0. Its temperature optimum is around 30 degrees C, ...

Let p, with or without subscripts, always denote a prime number. In this paper we are able to establish two localized results on a theorem of Prachar which states that almost all positive even integers n can be written as n = p2 + p3 + p4 + p5. As a consequence of one result, we prove additionally that each sufficiently large odd integer N can be represented as N = p1+p2+p3+p4+p5 with ∣pkk − 5 ...

A series of 2'-5'-linked oligo(adenylic acid) triphosphate (2'-5' A) inhibitors of protein synthesis were described recently. These inhibitors are synthesized from ATP by an enzyme activated in interferon-treated cell extracts or rabbit reticulocyte lysates by double-stranded RNA. We show here that 2'-5' A is a potent inhibitor of protein synthesis in intact cells of different origin (human, mo...

•Developed four functional click-enabled analogues of pregnenolone (P5)•Chemoproteomics prioritizes 62 P5 target proteins in live cancer and immune cells•These include shared distinct biochemical role cells•P5 activity cells is mediated through non-genomic pathways Pregnenolone (P5) promotes prostate cell growth, de novo synthesis intratumoural a potential cause development castration resistanc...