Seventeen non-directed td- (thymidylate synthase-deficient) splicing-defective mutations isolated in phage T4 were localized within the catalytic core of the ribozyme. All of the mutations occur in conserved structural elements that form part of the td intron core secondary structure. Remarkably, seven of the seventeen independently isolated mutations clustered in the dinucleotide 5' element (P...

Outer membrane protein P6 is the subject of investigation as a vaccine antigen to prevent infections caused by nontypeable Haemophilus influenzae, which causes otitis media in children and respiratory tract infections in adults with chronic lung disease. P6 induces protective immune responses in animal models and is the target of potentially protective immune responses in humans. P6 is a 16-kDa...

Let G be a finite undirected graph. A vertex dominates itself and all its neighbors in G. A vertex set D is an efficient dominating set (e.d. for short) of G if every vertex of G is dominated by exactly one vertex of D. The Efficient Domination (ED) problem, which asks for the existence of an e.d. in G, is known to be NP-complete even for very restricted graph classes such as P7-free chordal gr...

Up to now, it is still unknown whether microcirculation of deeper peripheral tissue (knee) can be modulated by acupuncture or acupressure on a meridian acupoint. The goal of this pilot study was to investigate possible effects of acupressure at the Xiyangguan acupoint (GB33) on the regional oxygen saturation of the deeper knee tissues by near-infrared spectroscopy (NIRS). Twelve healthy volunte...

The purpose of this study was to characterize the degree of antigenic heterogeneity or conservation of a 16,600-dalton outer membrane protein (P6) among strains of nontypable Haemophilus influenzae. Immunization of rabbits with P6 isolated from individual strains resulted in antibody to P6 of all 25 strains tested. The titers of antibody in the sera were similar among the strains. Whole organis...

Methods We performed a secondary analysis of 142 obese participants who had lost at least 10 pounds in a conventional weight loss program and who were randomized to the experimental weight loss maintenance intervention. This experimental intervention consisted of instruction and application of an energy psychology intervention, Tapas Acupressure Technique (TAT). TAT practice combined self-acupr...