Morphogenesis is driven by small cell shape changes that modulate tissue organization. Apical surfaces of proliferating epithelial sheets have been particularly well studied. Currently, it is accepted that a stereotyped distribution of cellular polygons is conserved in proliferating tissues among metazoans. In this work, we challenge these previous findings showing that diverse natural packed t...

BACKGROUND Published analyses of clinical outcomes for patients requiring large-volume blood transfusion conflict with respect to the impact upon plasma potassium levels. We analyzed a cohort of trauma patients to ascertain the impact of component product transfusion upon plasma potassium values. METHODS We performed an observational analysis of previously, prospectively collected clinical da...

Recent observations demonstrate that confluent tissues exhibit features of glassy dynamics, such as caging behavior and dynamical heterogeneities, although it has remained unclear how single-cell properties control this behavior. Here we develop numerical and theoretical models to calculate energy barriers to cell rearrangements, which help govern cell migration in cell monolayers. In contrast ...

OBJECTIVE This study analyzed the factors that are associated with the need for packed red blood cell transfusions in premature infants in a neonatal intensive care unit. METHODS This study is a cross-sectional study of secondary data from premature infants who were admitted to a neonatal intensive care unit between 2008 and 2010. Premature infants with low birth weight were included. Packed ...

A 31-year-old Native American/ white female with Type 1 diabetes mellitus of 26 years duration enrolled in the international multicenter trial of the Immune Tolerance Network (NS01) to replicate the Edmonton Protocol for islet transplantation. She used oral contraceptives. She had undergone two prior islet transplant procedures complicated by sirolimus induced mucositis, diarrhea, and anemia, t...

Corresponding author: Sang Mook Lee, M.D., Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Daejeon St. Mary’s Hospital. 520-2, Daeheung-dong, Jung-gu, Daejeon 301-723, Korea. Tel: 82-42-220-9046, Fax: 82-42-242-3500, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution...

The effect of changes in packed cell volume was studied in two commonly used reagent strip methods (Dextrostix and Reflotest) of measuring blood glucose and in a filter paper blood spot method. It was found that the results with both the reagent strip methods were greatly haematocrit-dependent. Attention is drawn to the possibility of false diagnoses of hypoglycaemia in haemoconcentrated patien...

The relationship between alcuronium requirements and the plasma concentration of albumin and total globulin was investigated in 50 adult patients undergoing elective upper abdominal surgery. No significant correlation was obtained with the plasma proteins (g/100 ml plasma). A significant positive correlation between alcuronium requirements and plasma albumin X (1-PCV), especially in anaemic pat...

AIM To evaluate the relative importance of biochemical markers of antioxidant status, gestational age, and parameters of neonatal care in the clinical outcome of premature infants. METHOD A prospective, observational, longitudinal study of the association between these factors was conducted. Blood was collected from an in situ arterial line within two hours of birth and at intervals thereafte...