Earth is unique in the Solar System as only planet characterised by an active plate tectonic regime. However, there still no consensus on whether this was fully operational Archaean or if it did not develop until Proterozoic. The metamorphic record offers valuable insight into debate, since paired, high and low T/P conditions are a hallmark of modern tectonics. much rock has either been eroded ...

Previous research in North America has supported the view that male involvement in committed, romantic relationships is associated with lower testosterone (T) levels. Here, we test the prediction that undergraduate men involved in committed, romantic relationships (paired) will have lower T levels than men not involved in such relationships (unpaired). Further, we also test whether these differ...

Background The prognostic significance of the number of tumorinfiltrating T cells has been demonstrated for many tumor types. In contrast, the significance of the tumorinfiltrating T cell clonality, which reflects the preferential infiltration or expansion of T cell clones in the tumor microenvironment, has not been clear because of the technical hurdles required for evaluating each T cell clon...

Abstract Both tumor-infiltrating lymphocytes (TIL) and PD-1+ peripheral blood (PBL) are enriched for tumor-reactive clones recognizing known unknown tumor antigens. However, the relationship between T-cell receptor-? (TCR?) repertoires of TILs T cells expanded from paired PBLs, whether PBLs can be used to treat patients with cancer as TIL substitutes remain unclear. Here, we established a highl...

The challenge hypothesis proposes that testosterone (T) elevation above what is needed for breeding is associated with social factors, and males possibly modulate their hormonal response to variations in population density and sex ratio. We investigated the role of social environment in altering testosterone levels and aggression in a tropical, seasonally breeding grassquit (Volatinia jacarina)...

The tau protein is a neuronal microtubule-associated protein. Apart of its physiological function-the binding to and stabilization of microtubules-tau is found in Alzheimer's disease brain as insoluble fibers, the so-called "paired helical filaments" (PHFs). Investigating the fundamentals of tau polymerization is indispensable for identifying inhibitory conditions or compounds preventing PHF fo...

This study aims to determine the effectiveness of literacy-numeration model in increasing educational learning independence for class teachers and students at Madrasah Ibtidaiyah , Magelang Regency, Indonesia. Qualitative quantitative approaches were used as research methods. Data collected by using interviews, observation, documentation techniques. The data then analysed with hypothesis test, ...