Introduction Antipsychotics are medications with an array of FDA approved indications in the field psychiatry including Schizophrenia, Bipolar Mania, Depression, Maintenance treatment for Disorder, Schizoaffective as well Adjunct Unipolar Depression and Tic disorders, among other non-adult patients. widely used psychiatric inpatient units throughout United States, globally. We observed trends a...

METHODS • Schizophrenia is a severe mental disorder, characterized by profound disruptions in thinking and affecting language, perception, and the sense of self.[1] This disabling and emotionally devastating illness is manifested by ‘positive’ (e.g. delusion, hallucinations) and ‘negative’ (e.g. blunted affect, alogia) symptoms. • In 2005, the prevalence of schizophrenia patients in France was ...

BACKGROUND Persons with schizophrenia often come in contact with the criminal justice system (CJS). This analysis of subjects with schizophrenia and a history of contact with the CJS estimated and compared mean cumulative function (MCF) of treatment failure events when treated with paliperidone palmitate (PP) or oral antipsychotics (OAs). All events identified during the full study period of th...

Long-acting injectable (LAI) antipsychotic formulations are increasingly used for improving patient compliance and long-term outcomes. Transitioning to LAIs raises questions regarding how optimum efficacy can be rapidly achieved while minimizing potential efficacy and safety concerns related to overlapping plasma levels of prior treatments and the new LAI. Ideally, randomized clinical trials wo...

Risperidone, paliperidone, quetiapine, olanzapine, and aripiprazole are antipsychotic drugs approved for treating various psychiatric disorders, including schizophrenia. The objective of this randomized, parallel-group, open-label study was to compare finger-stick-based capillary with corresponding venous whole-blood and plasma concentrations for these drugs after administration of a single dos...

This open-label, single-arm, multicenter, 13-week, prospective study explored the efficacy, safety, and tolerability of paliperidone palmitate (150 milligram equivalents [mg eq] [day 1], 100 mg eq [day 8], both deltoid injections; 75-150 mg eq, deltoid/gluteal injection) in Chinese patients with acute schizophrenia (Positive and Negative Syndrome Scale [PANSS] total score ≥70), who previously h...