نتایج جستجو برای: panss
تعداد نتایج: 1295 فیلتر نتایج به سال:
BACKGROUND The limitations of antipsychotics for treatment of schizophrenia have led to investigation of the usefulness of pharmacological augmentation strategies. Clinical studies have provided evidence for glutamate abnormalities in schizophrenia. Topiramate is an anticonvulsant drug with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist properties; therefore, the o...
OBJECTIVE The purpose of this study was to compare the sensitivity of four generic effectiveness measures with clinically meaningful symptom improvement in persons with schizophrenia. METHOD Baseline and 6-month interviews were conducted with 134 subjects diagnosed with schizophrenia or schizoaffective disorder. The design was observational. The four generic effectiveness measures included th...
Recent thought on grammatical architectures have underlined some discriminating features of the syntax-semantics interface: their syntactocentric nature when syntactic structures are mapped or transduced to semantics (and phonology); or their parallel nature, when semantics (and phonology) communicates with syntax via a nondirectional (or relational) interface. This duality arises for instance ...
The variable results of positive-negative research with schizophrenics underscore the importance of well-characterized, standardized measurement techniques. We report on the development and initial standardization of the Positive and Negative Syndrome Scale (PANSS) for typological and dimensional assessment. Based on two established psychiatric rating systems, the 30-item PANSS was conceived as...
با توجه به شیوع بالای تعداد افرادی که با بی قراری روان پریشانه (سایکوتیک) به مراکز فوریت های روان پزشکی مراجعه می کنند یافتن درمانی که موثر و با عارضه کمتر باشد، بسیار مطلوب است. نظر به گزارش هایی که در جهان در مورد اثربخشی داروهای ضد روان پریشی نامعمول (آتیپیک) حتی به صورت خوراکی در کنترل بی قراری روان پریشانه وجود دارد، محققین بر آن شدند که اثر رسپیریدون خوراکی (یک داروی ضد روان پریشی نامعمول...
BACKGROUND It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. METHODS We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patie...
OBJECTIVE To evaluate the safety and effectiveness of lurasidone in the long-term treatment of patients with schizophrenia. METHODS Patients who completed a 6-week, double-blind (DB), placebo-controlled trial continued in a 22-month, open-label (OL) study during which they received once-daily, flexible-doses of lurasidone, 40-120 mg. Change in the Positive and Negative Syndrome Scale (PANSS) ...
BACKGROUND Lifestyle moderate-intensity physical activity can lower the risk of over twenty chronic health conditions, whilst inactivity reduces daily functioning and physical health of individuals living with schizophrenia. This study conducted in 2014 examines the effect of structured walking participation on QOL, psychosocial functioning and symptoms in Hospital Permai, one of the largest ps...
OBJECTIVE To evaluate aripiprazole once-monthly (AOM), a long-acting injectable suspension of aripiprazole, as acute treatment in patients with schizophrenia (DSM-IV-TR). METHOD Adults experiencing an acute psychotic episode were randomized to 12 weeks of double-blind treatment with AOM 400 mg or placebo (October 2012-August 2013). The primary efficacy outcome was change from baseline to endp...
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