The pathophysiology of psoriasis, an autoimmune skin disorder, that affects approximately 3% the population worldwide, is incompletely understood, despite advanced knowledge. In this study, we investigated role and contribution mTOR signaling in myeloid lineage cells regulating pathogenesis systemic inflammation associated with psoriasis. We first established a genetic mouse model which was spe...

Psoriasis vulgaris is an autoimmune disease that influenced by multifactor, namely environmental, genetic (HLA-Cw6), and immune system dysregulation (IL-17 or IL-22), resulting in increased proliferation of keratinosit the epidermis. Histologically characterized parakeratosis, hyperkeratosis, elongated rete ridge, Monro micro abscess, Kogoj abscess. The clinical picture red patches with thick s...

Introduction: Increasing the volume of penis by injecting various substances (paraffin, silicone, mineral oils) remains a highly controversial procedure. This procedure is usually performed patients themselves or persons without licensed medical education. Injecting these causes local inflammatory reaction with redness, pain, swelling, thickening penile skin, subsequent formation sclerosing lip...

A 53-year-old woman with end-stage kidney failure from IgA nephropathy has been treated with haemodialysis for 14 years via the left forearm arteriovenous fistula (AVF). In August 2007, she developed an area of skin necrosis at the puncture site of AVF that was soon covered with a callus-like wrap. The puncture site was removed distally. In January 2008, a horn-like structure started to grow fr...

We believe that axillary granular parakeratosis, tinea pedis, and Seborrheic dermatitis are likely to be variants of eczema. All had culturable staphylococci capable of producing biofilms, as in eczema. This was confirmed on XTT assays, Congo red cultures, and PCR for gene analysis of the biofilm-forming icaD and aap genes. The pathology showed eccrine ductal occlusion that was noted on H+E and...

pustules were present concurrently. The patient complained of occasional pruritus and burning. Chronic plaque psoriasis on elbows was confirmed seven years before, for which she received topical corticosteroids. Focal infections were not found on clinical examination. It is important to note that the patient’s smoking habit aggravated the condition. Palmoplantar pustular psoriasis was diagnosed...

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of ...

BACKGROUND Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. The patients with atopic dermatitis are highly sensitized with mite allergens such as Dermatophagoides farinae (Df). Therefore, in the present study, we tried to develop a novel model for atopic dermatitis by...

Objective: Some previous studies have shown important modifications of the basement membrane of psoriatic skin, which could play a key role in alterations of keratinocyte proliferation and differentiation. Changes in distribution of the laminin α1 chain, together with fibronectin, might influence keratinocyte growth, and thus could be responsible for the initiation of psoriasis. In the view of ...