Calcium homeostasis is achieved by the interplay of a number of humoral agents (1). Of central importance are the activities of parathyroid hormone (PTH) and of vitamin D. This was fully appreciated 35 years ago (2), but in spite of considerable effort, the nature of the relationship remains controversial. Recent opinion has varied from that of a complete dependence of hormone action upon the p...

Hypoparathyroidism is characterized by insufficient parathyroid hormone (PTH) release from the glands to maintain serum calcium level within normal limits and unresponsiveness of target tissues despite PTH level. defined as low or inappropriately In this narrative review, we discuss etiology hypoparathyroidism in children.

introduction: radio-guided parathyroid surgery along with other minimally invasive surgeries constitutes the main surgical treatment procedures for different kinds of hyperparathyroidism.  in this article we have reported our experience of radio-guided parathyroid surgery using tc-99m sestamibi. methods: ten patients with hyperparathyroidism included in our study. twenty mci of tc-99m sestamibi...

Backgrounds: Chronic kidney disease (CKD) is an abnormality in the that lasts for more than 3 months. Increased phosphate levels blood due to CKD will stimulate secretion of Fibroblast Growth Factor 23 (FGF-23). FGF-23 happens maintain balance because capacity excretion phosphorus kidneys decreases and leads incidence secondary hyperparathyroidism Parathyroid Hormone (PTH). This study aims eval...

An 8-15S RNA fraction from calf parathyroid glands stimulated the incorporation of radioactive lysine and methionine into protein by 15- to 30-fold in a wheat germ extract. The major product, representing 25% of the total protein synthesized, could be bound to an antiserum to parathyroid hormone and binding was inhibited by parathyroid hormone. The chromatographic mobilities of the two tryptic ...

Plasma ionized calcium, platelet cytosolic calcium (using the fura-2 method in gel-filtered platelets), parathyroid hormone (both the intact hormone and a midmolecule portion), calcitriol, and calcidiol were measured in 19 untreated male patients with essential hypertension and 19 age-matched normotensive male research subjects. Mean levels of platelet cytosolic calcium, parathyroid hormone, ca...

An adult patient presenting in summertime with sarcoidosis and demonstrating raised levels of serum calcium and 1,25-dihydroxycholecalciferol was observed to have a serum immuno-reactive parathyroid hormone concentration in the mid-normal range. Renal function was normal. Corticosteroid administration quickly depressed serum calcium and 1,25-dihydroxycholecalciferol into the normal range; serum...

A severe form of I-cell disease (mucolipidosis II) can present in the newborn period as multiple fractures. The bone disease in these patients is believed to be due to hyperparathyroidism. We report a case where bone disease was present at birth but the parathyroid hormone levels were initially normal and did not increase until 37 d of age. Supplemention with vitamin D was needed to normalize t...