Flow chemistry-based syntheses of deuterium-labeled analogs of important antidiabetic chalcones were achieved via highly controlled partial C≡C bond deuteration of the corresponding 1,3-diphenylalkynones. The benefits of a scalable continuous process in combination with on-demand electrolytic D2 gas generation were exploited to suppress undesired over-reactions and to maximize reaction rates si...

We studied the efficacy and implementation outcomes of a culturally responsive parent training (PT) program. Fifty-four Chinese American parents participated in a wait-list controlled group randomized trial (32 immediate treatment, 22 delayed treatment) of a 14-week intervention designed to address the needs of high-risk immigrant families. Parents were eligible for intervention if they were Ch...

Lexical comprehension is commonly measured by parent report, but it may be difficult for parents of children with ASD to accurately judge their child's comprehension. We compared parent report to an eye-gaze measure of lexical comprehension in which participants observed pairs of images on a screen, along with accompanying speech that named one of the two images. Twenty-two toddlers with ASD pa...

10 Variations in the germination and malting performance during storage of three Canadian 11 malting barley varieties AC Metcalfe, CDC Kendall and CDC Copeland, which had 12 suffered from different degrees of pre-harvest sprouting damage (PHSD) at harvest, 13 were examined. These barley samples were collected in Saskatchewan, Canada during 14 two successive crop years (2007-2008). During storag...

Smith (1971) described a method for deriving the recurrence risk of conditions with multifactorial inheritance in non-consanguineous families. In our paper the method is extended to those cases in which the parents are related. Some results are presented of specific examples in order to give some idea of the increased risk caused by consanguinity in some of the simple cases likely to be met in ...

BACKGROUND The Patient-Oriented Eczema Measure (POEM) has been recommended as the core patient-reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema. ME...

A two-step strategy for disaccharide modulation using vancomycin as a model is reported. The strategy relies upon a glycosyltransferase-catalyzed 'reverse' reaction to enable the facile attachment of an alkoxyamine-bearing sugar to the vancomycin core. Neoglycosylation of the corresponding aglycon led to a novel set of vancomycin 1,6-disaccharide variants. While the in vitro antibacterial prope...

Genetic variation for thermal plasticity plays an important role in the success or failure of a species with respect to the colonization of different thermal habitats and the ability to deal with climatic change. The aim of this paper is to study the relative contribution of the additive and non-additive components of genetic variation for the slope of the temperature reaction norm for juvenile...