Background Detection and sequencing of circulating microbial cell-free DNA (mcfDNA) in plasma is an increasingly popular tool for diagnosing many infectious diseases, but could also be used to monitor the progress infection. However, decay this blood following treatment has not been previously characterized. Case Presentation A 53 year-old male was diagnosed with Bartonella quintana bioprosthet...

Acute bacterial meningitis (ABM) is a potentially life-threatening neurological emergency. An agreed protocol for early, evidence-based and effective management of community-acquired ABM is essential for best possible outcome. A literature search of peer-reviewed articles on ABM was used to collect data on the management of ABM in older children and adults. Based on the strength of published ev...

OBJECTIVE Outpatient parenteral antimicrobial therapy (OPAT) is increasingly used to treat children at home, but studies in children are scarce. We aimed to describe the use, appropriateness and outcomes of OPAT in children. DESIGN This was a 12-month prospective observational study. SETTING The hospital-in-the-home programme of The Royal Children's Hospital Melbourne. PATIENTS All patien...

OBJECTIVE To study the effect of an educational intervention on the management of hospitalized infants with bronchiolitis. DESIGN Sequential, prospective cohort study. SETTING A 235-bed children's hospital with nearly all private rooms. PATIENTS Consecutively admitted, previously healthy children younger than 24 months with symptoms of bronchiolitis. The first cohort was enrolled between ...

INTRODUCTION Gram negative organisms are one of the major causes of nosocomial diseases. Development of resistance to antibiotics by these organisms increases their risk in clinical treatment of patients. It also affects morbidity and mortality hence needs to be monitored and controlled. AIM The aim of the present study was to analyse the correlation between consumption of parenteral antibiot...

OBJECTIVES To evaluate the feasibility, efficacy, and cost of outpatient parenteral antimicrobial therapy (OPAT) in the treatment of osteomyelitis. SUBJECTS 39 patients with an osteomyelitis requiring parenterally administered antibiotics for more than 4 weeks, and able to receive antibiotics at home. METHODS All patients had a totally implanted catheter. Antibiotics were administered by co...

The study was conducted to evaluate the Antibiotic Stewardship Program (ASP) in Korean hospitals compared with the previous two surveys in 2006 and 2012. The information on ASPs was collected through an online-based survey sent by e-mail to 192 infectious diseases specialists in 101 Korean hospitals in September 2015. Fifty-four hospitals (53.5%, 54/101) responded to the online survey. One infe...

Introduction: Due to complex dosage calculations, requirement and different pharmacokinetics profile of drugs in paediatric population, there is a risk development drug resistance due the excessive inappropriate use antibiotics. The aim this study determine antibiotic prescriptions pattern analyse rationale patient. Methods: A prospective observational was carried out for period six months. Dat...