In This Issue In This Issue ROCK and Rho will never Dia irectional migration of a cell requires both lamellipodia formation at the leading edge and actomyosin contraction within the tail. New results from Tsuji et al. (page 819) indicate that Rho may mediate both tasks, and that these two arms of Rho signaling are antagonistic. Rho signaling is known to mediate the formation of stress fibers, s...

This paper describes a design methodology for the basic current source cell circuit of high-speed high-accuracy current steering DIA conveners taking into account mismatching in all the transistors of the cell. Previous works consider arbitrary safety margins in the sizing process. The presented approach allows a more accurale selection of the optimal design point. The design methodology is ill...

The transition to adult care �or adolescents �ith dia�e� tes is a complex issue, and several studies have sho�n that one o� the important �arriers to success�ul transi� tions is the health care system itsel�. Adolescence is also a vulnera�le time in li�e as many o� the patterns o� sel��care �ehaviour are set �hich coincides �ith a struggle �or independence �rom adults. The overall aim o� this ...

This paper attempts to demonstrate the principles of hermeneutics in an effort to understand factors affecting Information Systems (IS) projects. As hermeneutics provides a systematic method of interpreting text from multiple information sources, thus, Information Systems being prima facie defined and documented as text documents, are eminently suited for this mode of investigation. In this pap...

We present an approach for the semantic integration of geoscience data, and a system implementing this approach. Specifically, we demonstrate the use of data ontologies and application of markup languages for semantic integration of data and services. We introduce a domain level object ontology, called Earth and Planetary ONTology (EPONT) to explore, extract, and integrate information from hete...

The very small scales of isotropic, Navier-Stokes turbulence at Reynolds number Rλ ≈ 15 are studied by high-resolution direct numerical simulation (DNS) and by integration of the direct-interaction (DIA) equations. The DNS follows the tail of the energy spectrum over more than thirty decades of magnitude. The energy spectrum in the far-dissipation range 5kd < k < 10kd is well-fitted by k α exp(...

Mammalian and fungal Diaphanous-related formin homology (DRF) proteins contain several regions of conserved sequence homology. These include an amino-terminal GTPase binding domain (GBD) that interacts with activated Rho family members and formin homology domains that mediate targeting or interactions with signaling kinases and actin-binding proteins. DRFs also contain a conserved Dia-autoregul...

Estudou-se a interação de atrazina (AT), propazina (PROP), desetil-atrazina (DEA), deisopropilatrazina (DIA) e hidroxi-atrazina (HAT) com o argilomineral vermiculita saturado com K (VTK) e com VTK modificada pela incorporação de hexadeciltrimetil-amônio (HDTMA-VT) no espaço interlamelar. A VTK bruta teve interação desprezível com AT, PROP e DEA, interação moderada com DIA e forte interação com ...