● Context.—Fondaparinux, a factor Xa inhibitor, is approved for thromboprophylaxis after orthopedic surgery and for treatment of venous thromboembolism. It may also be efficacious, safe, and cost-effective for other patients; thus, more widespread use of fondaparinux is likely. The effect of fondaparinux on coagulation testing needs to be thoroughly examined. Objective.—To report the effects of...

the article “oral manifestation in transplant patients” was read with enthusiasm.[1] however, the following points may be noted worthy. fissured tongue, atrophy of tongue papillae, and angular cheilitis can be observed in liver transplant patients and these may be due to concurrent hyposalivation, due to intake of diuretic drugs such as thiazides and loop diuretics.[2,3] excessive bleeding with...

INTRODUCTION The most commonly used test for monitoring heparin therapy is the activated partial thromboplastin time (aPTT). The response of available aPTT reagents to heparin varies significantly. The aim of this study was to highlight the differences between aPTT reagents stored in a dried format to select the most suitable formulations to be used for the development of point-of-care diagnost...

OBJECTIVE To determine the optimum storage temperature and time for prothrombin time and activated partial thromboplastin time at various intervals at both room temperature and refrigerator. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Advanced Medical and Dental Institute (AMDI), Laboratory at University Sains Malaysia (USM), from August 2009 to June 2010. METHODOLOGY Aft...

OBJECTIVE This study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus. METHODS APTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG) and glycosylated hemoglobin A1c (HbA1c) levels were measured in 1,300 patients. Patients were divided into three groups according to the...

Evidence for Abnormalities in Clotting and Thrombolysis as a Risk Factor for Stroke • Four hundred six patients with ischemic thrombotic cerebrovascular disease (ITCVD) and 115 age-matched controls were studied to select risk factors which would identify ITCVD-prone individuals from a healthy population. The following factors were evaluated: soluble fibrin, plasminogen, plasminogen activator, f...

CONTEXT Preanalytical factors influencing the reliability of laboratory testing are commonplace. It is traditionally accepted that hemolytic samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells. OBJECTIVE To evaluate the influence of blood cell lysis on routine coagulation testing. ...

In this paper, we define (i) unrestricted (UT), (ii) restricted (RT) and (iii) pre-test (PTT) tests for testing the significance of a subset of the parameters of a multiple regression model when the remaining parameters are (i) completely unspecified, (ii) specified at fixed values or (iii) suspected at fixed values. The M-estimation methodology is used to formulate the three tests. The asympto...