Solanezumab (Eli Lilly) and crenezumab (Genentech) are the leading clinical antibodies targeting Amyloid-β (Aβ) to be tested in multiple Phase III clinical trials for the prevention of Alzheimer's disease in at-risk individuals. Aβ capture by these clinical antibodies is explained here with the first reported mid-region Aβ-anti-Aβ complex crystal structure. Solanezumab accommodates a large Aβ e...

the glass transition temperature (tg) and the melting temperature (tm) of gelatin at water contents between 7 and 14% were measured using differential scanning calorimetry.  the plasticisation of the polymer by water led to a decrease in tg and tm. the tg of partially crystalline gelatin was higher than that of the amorphous one obtained by quenching from the melt. the enthalpy relaxation occur...

The ionizable amino acid side chains of proteins are usually located at the surface. However, in some proteins an ionizable group is embedded in an apolar internal region. Such buried ionizable groups destabilize the protein and may trigger conformational changes in response to pH variations. Because of the prohibitive energetic cost of transferring a charged group from water to an apolar mediu...

Introduction: Lunar volcanism creates a wide variety of features such as domes, rilles, and large pyroclastic deposits. Mapping the subsurface column structure of the upper part of these deposits can provide key information about how they were formed and how the surface regolith developed through subsequent weathering. In addition, many possible lunar landing sites (e.g., the Constellation site...

Motivated by a 3D printing company, ExOne, the goal of this project is to recognize 3D objects from partially observed surface data. Given point cloud data of a buried object from a Kinect, as well as the entire CAD model of the object, the aim is to determine the object's orientation in space. To accomplish this task, we implemented a Hough Voting algorithm for object detection and localizatio...

While carbon capture and storage (CCS) is increasingly recognised as technologically possible, recent evidence from deep-sea CCS activities suggests that leakage from reservoirs may result in highly CO2 impacted biological communities. In contrast, shallow marine waters have higher primary productivity which may partially mitigate this leakage. We used natural CO2 seeps in shallow marine waters...

Variations in the dental crown form are widely studied to interpret evolutionary changes in primates as well as to assess affinities among human archeological populations. Compared to external metrics of dental crown size and shape, variables including the internal structures such as enamel thickness, tissue proportions, and the three-dimensional shape of enamel-dentin junction (EDJ), have been...

Shallow bias tunnels are sensitive at the entrance section, where existence of soil–rock interface (SRI) results in more complex deformation surrounding rock and supporting structure. This study investigates mechanical properties structure a shallow-buried tunnel crossing by combination model tests numerical simulations. A biased with significant cracking its section is selected southwest China...

We studied the response of high-resistivity MOS CCDs to monochromatic X-ray illumination at energies ranging from 1.47 to 5.9 keV and discovered a new feature in the low-energy tail of the response function. We attribute it to the photons interacting in the gate insulator and explain the shape of the entire low-energy tail assuming that it is formed by electron charge clouds partially formed in...

The self-organization of three dimensional quantum dot superlattices that spontaneously form during heteroepitaxial growth is investigated by using a three dimensional kinetic model. The model predictions show that the multilayer arrays of quantum dots can be fully or partially aligned vertically, or completely misaligned with respect to the buried islands, depending on the thickness of the spa...