OBJECTIVES To determine whether parvovirus B19 (B19) infection is associated with rheumatoid arthritis (RA). METHODS The polymerase chain reaction was applied to serum, cells isolated from synovial fluid, and synovial fluid. Enzyme immunoassay technique was used to detect antibodies against B19. RESULTS Of 142 patients with early RA (onset of disease under one year) and 67 control patients,...

Human parvovirus B19 is considered an etiologic agent of aplastic anemia in immunosuppressed patients. Microscopic vasculitis, with or without renal involvement, has recently been attributed to this viral infection in immunocompetent patients. This study describes four cases of thrombotic renal graft microangiopathy presumably secondary to B19 infection. Twelve to 50 days after transplantation,...

The blood group P antigen, known to be abundantly expressed on erythroid cells, has been reported to be the cellular receptor for parvovirus B19. We have described the development of recombinant parvovirus B19 vectors with which high-efficiency, erythroid lineage-restricted transduction can be achieved (S. Ponnazhagan, K. A. Weigel, S. P. Raikwar, P. Mukherjee, M. C. Yoder, and A. Srivastava, J...

BACKGROUND The incidence of acute symptomatic (at the time of documented brain insult) seizures and single unprovoked seizures are 29-39 and 23-61 per 100 000 per year, respectively. After stabilization of the patient, finding the etiology of the seizure is of paramount importance. A careful history and physical examination may allow a diagnosis without need for further evaluation. METHODS In...

Parvovirus (PV) B19 is the causative agent of the childhood disease erythema infectiosum. An association of PV B19 with chronic arthropathies, sometimes resembling rheumatoid arthritis or juvenile idiopathic arthritis (JIA), has repeatedly been described. Other studies, however, have failed to identify any such relationship. In order to study further whether there is a link between PV B19 and J...

B19 parvovirus, the cause of fifth disease and transient aplastic crisis, has been successfully propagated in suspension cultures of human erythroid bone marrow cells obtained from patients with sickle cell disease and stimulated by erythropoietin. B19 inoculation in vitro resulted in a marked decline in identifiable erythroid cells over seven to nine days of incubation. Characteristic giant ea...

The transcription profile of chipmunk parvovirus (ChpPV), a tentative member of the genus Erythrovirus in the subfamily Parvovirinae of the family Parvoviridae, was characterized by transfecting a nearly full-length genome. We found that it is unique from the profiles of human parvovirus B19 and simian parvovirus, the members in the genus Erythrovirus so far characterized, in that the small RNA...

Parvovirus B19 (PV B19) is a nonenveloped single-stranded DNA virus that causes wide variety of diseases ranging from benign childhood infection such as slapped-cheek syndrome to life threatening hydrous fetalis in fetuses or aplastic anemic crises patients with hemolytic anemia. In immunocompromised hosts including organ transplant recipients, PV has incorporated into red blood cell progenitor...

El Hidrops fetal es la acumulación anormal de líquido en al menos 2 compartimientos fetales. Su origen puede ser inmune o no inmune. parvovirus B19 responsable una parte importante los casos hidrops pronóstico ante esta entidad, malo, y presenta alta mortalidad. Se presentar un caso clínico gestante con feto afectado por secundario a anemia severa, causada infección B19, manejado mediante trans...