The classification of diseases has several important applications ranging from diagnosis and choice of treatment to demographics. To date, classifications have been successfully created manually, often within international consortia. Some groups of diseases, such as primary immunodeficiencies (PIDs), are especially hard to nosologically cluster due, on one hand, to the presence of a wide variet...

A field study was carried out to evaluate the effect of vaccination against swine enzootic pneumonia in different production systems (closed or one-site, and open, two- or three-site, systems). The percentage of mortality showed statistically significant differences (p < 0.001) in favour of vaccination in all the production systems examined. Zootechnical and economic parameters also reflected t...

DNA and histone methylation are both modifications closely link to stable repression. However, previous studies have shown that methylation repression by EZH2 could be an independent epigenetic mechanism of DNA methylation [1]. EZH2 protein and H3K27me3 marks appear to favor the development of prostate cancer by modulating gene expression. These data underline the importance of EZH2 and H3K27me...

BACKGROUND/OBJECTIVE While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. Axillary lymph node metastasis (ALNM) is one of the most important prognostic determinants in breast carcinoma; however, the reasons why tumors vary ...

This paper presents the one-dimensional gait kinematic principle, in order to identify the kinematic parameters for normal and pathological (transtibial amputation) gait of two subjects with similar anthropometry. Each type of gait is associated with uniform linear motion and uniformly accelerated motion. We used the Manuela Beltrán University Biomechanics Laboratory. The developed physical mod...

OBJECTIVES To identify differentially expressed miRNA between oral squamous cell carcinoma (OSCC) and non-cancer (NC) and to associate these with clinico-pathological parameters. MATERIALS AND METHODS miRNA microarray profiling was utilized to obtain the expression profile of miRNAs in four OSCC and four NC samples. The expression of miR-31 and miR-375 was further validated in 26 OSCC and thr...

We previously reported that a 660-bp sequence that is homologous to the env gene of the mouse mammary tumor virus (MMTV) but not to endogenous retroviruses or to other known genes was present in 38% of human breast cancers and in some breast cancer cell lines studied (Y. Wang et al., Cancer Res., 55: 5173-5179, 1995). Here, we have investigated whether the MMTV-like sequences were associated wi...

BACKGROUND Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thus exploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathological parameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenic pathways. MATERIALS AND METHODS cDNAs from 41 OSCC samples with and witho...

The use of polarimetric techniques is nowadays widespread among solar and stellar astronomers. However, notwithstanding the recommandations that have often been made about the publication of polarimetric results in the astronomical literature, we are still far from having a standard protocol on which to conform. In this paper we review the basic definitions and the physical significance of the ...