BACKGROUND AND OBJECTIVE Our objective was to report on the design and essentials of the Etoricoxib protocol- Preemptive and Postoperative Analgesia (EPPA) Trial, investigating whether preemptive analgesia with cox-2 inhibitors is more efficacious than placebo in patients who receive either laparotomy or thoracotomy. DESIGN AND METHODS The study is a 2 x 2 factorial armed, double blinded, bic...

conclusions the ops is a good stand-alone pain score and is better than the nrs for defining mild and moderate pain. it may even be used to supplement nrs when it is indicative of mild or moderate pain. patient and methods a total of 1021 paired readings of the ops and nrs of 93 patients who underwent laparotomy and used patient-controlled analgesia were evaluated. acute pain service (aps) pers...

CONTEXT AND OBJECTIVE Post-thoracotomy pain is a severe and intense pain caused by trauma to ribs, muscles and peripheral nerves. The current study aimed to compare subpleural analgesia (SPA) with thoracic epidural analgesia (TEA) in patients undergoing thoracotomy. DESIGN AND SETTING Randomized study at Ankara Numune Education and Research Hospital, in Turkey. METHODS Thirty patients prese...

In children, patient controlled analgesia (PCA) and continuous infusion (CI) of morphine are well established methods of relieving postoperative pain. This study was designed to assess the efficacy of PCA plus background infusion (BI) (15 microg x kg(-1) x h(-1) and bolus doses of 15 microg x kg(-1) with a lock-out interval of 10 min) with CI (20 to 40 microg x kg(-1) x h(-1)) in terms of analg...

BACKGROUND We assessed the analgesic efficacy of parecoxib, acetaminophen, and the combination of both compared with placebo in patients undergoing elective thyroid or parathyroid surgery. METHODS We randomized 140 patients to receive one of the following i.v. treatments using a double-blinded double-dummy technique: placebo, 80 mg 24 h(-1) parecoxib, 5 g 24 h(-1) acetaminophen, or 80 mg pare...

BACKGROUND/AIM Postoperative pain control constitutes a major problem and studies have focused on reducing opioid requirements using regional techniques. We aimed to investigate the efficacy of wound infiltration with lornoxicam on postoperative pain control following thyroidectomy. MATERIALS AND METHODS In this prospective, randomized-controlled study, 80 patients scheduled for thyroidectomy...