The starting point for this collection of essays is the view that dominant interpretations European policy-making and governance are rooted in a conventional positivist approach seeks explanations based on commonality across multiple cases which actors' motivations practices reduced to some form fixed rationality or institutional assimilation. In order counter sidelining subjectivity agency edi...

Trimeric G protein signaling is a fundamental mechanism of cellular communication in eukaryotes. The core of this mechanism consists of activation of G proteins by the guanine-nucleotide exchange factor (GEF) activity of G protein coupled receptors. However, the duration and amplitude of G protein-mediated signaling are controlled by a complex network of accessory proteins that appeared and div...

In silico tools and resources are now used commonly in toxicology to support the “Next Generation Risk Assessment” (NGRA) of cosmetics ingredients or materials. This review provides an overview approaches that applied assess exposure hazard a cosmetic ingredient. For both exposure, databases existing information routinely. addition, for include use rules thumb systemic bioavailability as well p...

Nations and NationalismVolume 29, Issue 1 p. 383-385 BOOK REVIEW Nico Carpentier, Iconoclastic Controversies: A photographic inquiry into antagonistic nationalism. Bristol: Intellect, 2021, 166 pp, £ 30 (PBK) Mazlum Kemal Dagdelen, Corresponding Author Dagdelen [email protected] orcid.org/0000-0003-0064-4722 Institute of Communication Studies Journalism, Charles University, Prague, Czech Republ...

T-lymphokine-activated killer celloriginated protein kinase (TOPK) is known to be upregulated in cancer cells, and appears to contribute to cancer cells proliferation and survival. However, the molecular mechanism by which TOPK regulates cancer cells survival still remains elusive. Here we show that TOPK directly interacted with, and phosphorylated IB at Ser-32 leading to p65 nuclear transloc...

Two new species of the feather mite family Pteronyssidae Oudemans, 1941 are described from the white-barred piculet, Picumnus cirratus Temminck from Brazil: Pterotrogus picumni sp. n. and Ramphastobius scutatus sp. n., representing the first mites described from this host. Pterotrogus picumni sp. n. can be readily distinguished from all previous species of the simplex group by having dorsal cre...