The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and ?-caprolactone (PCL) nanofibers containing metronidazole amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment periodontal diseases. Scanning electron microscopy showed that PLGA PCL produced from uniform bead-free in morphology. obtained had a stro...

Abdominal hernia reparation constitutes the second surgical operation in world with more than 20 million cases per year. However, 50 % of all intra-abdominal operations, postoperative adhesions occur and result important pain for patients. These take place after excessive deposition fibrin between peritoneum organs within 7 days which occurs during coagulation cascade. For this reason, therapeu...

IMPORTANCE Cell seeding throughout the thickness of a nanofiber construct allows for patient-specific implant alternatives with long-lasting effects, earlier integration, and reduced inflammation when compared with traditional implants. Cell seeding may improve implant integration with host tissue; however, the effect of cell seeding on thick nanofiber constructs has not been studied. OBJECTI...

Electrospun organic/inorganic hybrid scaffolds have been appealing in tissue regeneration owing to the integrated physicochemical and biological performances. However, conventional electrospun with non-woven structures usually failed enable deep cell infiltration due densely stacked layers among fibers. Herein, through self-assembly-driven electrospinning, a polyhydroxybutyrate/poly(ε-caprolact...

In this study, Silk Fibroin (SF)/Polycaprolactone (PCL) composite nanofiber mats were fabricated using an electrostatic spinning technology employing different drum rotation speeds. The morphology and tensile performance of the resulting nanofiber mats were characterized using thermal field emission scanning electron microscopy, multi-layer image fusion technology, pore size distribution analys...