Disruption of iron homeostasis within the central nervous system (CNS) can lead to profound abnormalities during both development and aging in mammals. The radiation-induced polycythaemia (Pcm) mutation, a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), disrupts transcriptional and post-transcriptional regulation of this pivotal iron transporter. This regulatory mutation ind...

Potential effects of climate change on the hydrology and water resources of the Columbia River Basin were evaluated using simulations from by the U.S. Department of Energy and National Center for Atmospheric Research Parallel Climate Model (DOE/NCAR PCM). This study focuses on the implications for the water resources of the Columbia River basin using climate projections for the 21st century bas...

This paper initially describes the relational counterpart of possibilistic c-means (PCM) algorithm, called relational PCM (or RPCM). RPCM is then improved to better handle arbitrary dissimilarity data. First, a re-scaling of the PCM membership function is proposed in order to obtain zero membership values when the distance to prototype equals the maximum value allowed in bounded dissimilarity m...

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...

There is an increasing interest in developing Phase Change Memory (PCM) based main memory systems. In order to retain the latency benefits of DRAM, such systems typically have a small DRAM buffer as a part of the main memory. However, for these systems to be widely adopted, limitations of PCM such as low write endurance and expensive writes need to be addressed. In this paper, we propose PCMawa...

Abstruct-Research and development of coherent optical fiber communications have been accelerated mainly because of the possibility of receiver sensitivity improvement reaching 20 dB, and partly because of the possibility of frequency-division multiplexing (FDM) with very fine frequency separation. In this paper, recent advances in the research on coherent optical fiber communication systems are...

Cultured corneal epithelial cells release a factor(s) that stimulates trigeminal neurons to form neurites in vitro. To characterize this trophic effect, conditioned media (serum free, supplemented) from cultures for corneal epithelium, stromal fibroblasts, and endothelium were studied further. Only epithelial conditioned medium (PCM) prolonged neuronal survival and induced neurite outgrowth. Th...

Joubert syndrome (JS) is a developmental brain disorder characterized by cerebellar vermis hypoplasia, abnormal eye movement, ataxia and mental retardation. Mutations in CEP290 mutations are responsible for the cerebello-oculo-renal subtype of JS that includes kidney cysts and retinal degeneration, two phenotypes commonly linked to ciliopathies. CEP290 mutations are also associated with Meckel-...

The efficient use of nutrients is important in development and aging. In this study, we asked if the protein repair methyltransferase has a related or additional role in energy metabolism and stress response in the nematode Caenorhabditis elegans. Worms lacking the pcm-1 gene encoding this enzyme exhibit reduced longevity as SDS-isolated dauer larvae and as arrested L1 larvae under starvation s...

For several decades, computer’s memory has been volatile. High speed memories such as DRAM and SRAM have been used as main memory and cache memory respectively. Magnetic disks are used as the persistent secondary storage devices. The present DRAM based main memory has reached its energy limits. Due to the advent of nonvolatile memories like PCM, MRAM, RRAM, FeRAM and Flash, there is growing int...