The objective of this study was to predict the clinical bacteriological efficacy of antibiotics and to examine the pharmacodynamics (PD) characteristics of antibiotics against bacterial strains using a mechanism-based pharmacokinetic-pharmacodynamics (PK-PD) modeling developed on the basis of interaction between drug concentrations and antibacterial activities. Dynamic PD parameters (epsilon, g...

coeffcient of  friction  (cof)  for  rubber parts  is one of  the key parameters in their interaction with solid rough surfaces (micrometer to millimeter scales),  such  as  tire-road  interactions. cof  of  rubber  depends  on  viscoelastic properties of rubber, roughness characteristics of the counter-part surface, and process variables such as contact nominal pressure and sliding speed. due ...

Abstract – This document gives you a brief idea of the Design and simulation of DC/DC Boost converter using pulse width modulation based sliding mode controller operating in continuous conduction mode is discussed. The performance and properties of sliding mode controller is compared with conventional controllers Proportional Integral Derivative (PID) controller and Proportional Integral (PI) c...

This paper considers three variants of last-come first-served (LCFS) preemptive service single-server queues, where customers are served under the LCFS preemptive resume (LCFS-PR), preemptive repeat-different (LCFS-PD), and preemptive repeat-identical (LCFS-PI) disciplines, respectively. These LCFS queues are fed by multiple batch Markovian arrival streams. Service times of customers from each ...

This paper presents a new approach to Load Frequency Control (LFC) for a hydro-power plant. The control algorithm combines sliding mode control with H∞ technique. The dynamic model of an entire hydro-power plant has been developed. The sliding hyperplane is constructed by H∞ full state feedback control method. The ideal lossless turbine-penstock model is used in this paper to conduct the simula...

In this paper, a new approach to the super-twisting sliding mode control of uncertain systems is proposed. The idea behind this control scheme is to utilize an adaptive sliding surface function, in which the slope of the surface is updated on-line using a simple single input-single output fuzzy logic inference system so that the sliding surface is rotated in such a direction that the tracking p...

Abstract – This document gives you a brief idea of the Design and simulation of DC/DC Boost converter operating in continuous conduction mode using pulse width modulation based sliding mode controller. The performance and properties of sliding mode controller is compared with Proportional Integral Derivative (PID) controller and Proportional Integral (PI) controller. Simulation results shows th...

This paper introduces a new class of simple nonlinear PID controllers and provides a formal treatment of their stability analysis. These controllers are comprised of a sector-bounded nonlinear gain in cascade with a linear fixed-gain P, PD, PI, or PID controller. Three simple nonlinear gains are proposed: the sigmoidal function, the hyperbolic function, and the piecewise]linear function. The sy...

Output feedback sliding mode control has received great research interests, due to it does not require full accessibility of states and increases the ability of practical implementation of sliding mode control. In this paper, a new approach of chattering-free OFSMC design is proposed by incorporating integral sign function control for general multi-input multi-output linear uncertain systems. C...

Protocol deviations (PDs) may jeopardize safety, rights, and welfare of subjects and data integrity. There is scarce literature and no guidelines for Institutional Ethics Committees (IECs) to process PD reports. The PD reports submitted to IECs from Jan 2011 to August 2014 were analyzed retrospectively. Types of studies reporting PDs, category and type of PDs, PD rate per participant, time of r...