In the United States, acute gastroenteritis (AGE) is a significant cause of morbidity, accounting for approximately 179 million illnesses annually [1]. Noroviruses are recognized as the leading cause of AGE across all ages and are responsible for approximately 21 million annual illnesses. However, before 2006, rotaviruses accounted for the majority of severe AGE cases among children under 5 yea...

Knowledge about hepatotropic viruses is crucial for pediatricians because of the high prevalence of viral hepatitis during childhood. The multiplicity of hepatotropic viruses, the spectrum of acute and chronic infections, and the sequels of viral hepatitis result in a need for physicians to better understand the clinical and epidemiological context of patients with viral hepatitis, as well as t...

For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, we show that risk of severe deng...

The purpose of this work is to remind doctors practical medicine about the importance differential diagnosis with cancers in general pediatric practice and increase vigilance clinicians regarding similarity manifestations oncology infectious diseases on example specific clinical cases. We conducted an empirical, descriptive study 4 cases children. selected them among 21 patients who were diagno...

Viral infections are known to increase predilection stroke and coronavirus disease 2019 (COVID-19) has proven these concerns true. We presenting the case of a 6-year-old previously normal male child diagnosed with posterior circulation who had all etiological workups negative except for COVID antibody. Imaging showed thrombi over V3 segment vertebral artery at C1–C2 level causing near complete ...

The clinical aspects of SARS-CoV-2 infection, as well the COVID-19 vaccines’ safety, efficacy and effectiveness in pediatric patients with asthma, are crucial to adapting management this fragile population for prevention strategies. aim narrative review was evaluate impact infection children asthma vaccination. Systematic research using principal medical databases conducted specific search quer...

Diarrheal diseases remain a leading cause of global childhood mortality and morbidity. Several recent epidemiological studies highlight the rate of diarrheal diseases in different parts of the world and draw attention to the impact on childhood growth and survival. Despite the well-documented global burden of diarrheal diseases, currently there are no combination diarrheal vaccines, only licens...

To define the clinical manifestations and laboratory characteristics of pediatric severe fever with thrombocytopenia syndrome (SFTS) case caused by a novel bunyavirus. we retrospectively analyzed a pediatric case of viral SFTS in a 13 year old successfully managed and confirmed to be due to the novel bunyavirus now referred to as Huaiyangshan virus. A literature review of related cases was perf...

Systemic onset juvenile idiopathic arthritis (SoJIA) represents up to 20% of juvenile idiopathic arthritis. We recently reported that interleukin (IL) 1 is an important mediator of this disease and that IL-1 blockade induces clinical remission. However, lack of specificity of the initial systemic manifestations leads to delays in diagnosis and initiation of therapy. To develop a specific diagno...