In situ commissioning of the Blower-gun injector for launching cryogenic deuterium pellets at ASDEX Upgrade tokamak was performed. This injector is designed for high repetitive launch of small pellets for edge localised modes pacing experiments. During the investigation the final injection geometry was simulated with pellets passing to the torus through a 5.5 m long guiding tube. For investigat...

Microcrystalline cellulose (MCC) and powdered cellulose (PC) are commonly used excipients for solid dosage forms e.g., pellets. The aim of this study was to compare the utility of the MCC and PC in the floating pellet cores comprising verapamil hydrochloride (VH) manufactured by extrusion and spheronization and influence on their physical properties like swelling, compressibility and VH release...

OBJECTIVE To develop a biodegradable, modified-release antibiotic pellet capable of eradicating biofilms as a potential novel treatment for biofilm infections. DESIGN Pellets containing poly(DL-lactic-co-glycolic acid) microparticles, rifampin and clindamycin hydrochloride (3.5%, 7%, or 28% antibiotic by weight), and carrier gel (carboxymethylcellulose or poloxamer 407) were tested in vitro. ...

The aim of this study was to develop and optimize a segregation-free ethyl cellulose-coated extended release multiparticulate formulation to be compressed into tablets without affecting the drug release. Standard tableting excipients (e.g., microcrystalline cellulose, lactose or sorbitol) were layered onto ethyl cellulose-coated propranolol hydrochloride pellets to form a cushion layer in order...

BACKGROUND Patients, who survived from shotgun injuries, often have some retained lead pellets in their bodies. Several cases of lead toxicity have been reported regarding these patients. OBJECTIVES This study seeks to compare the serum lead level in patients who have retained lead pellets in their bodies with the control group. PATIENTS AND METHODS In this case-control study, we gathered t...

The deleterious effects of three cryoprotectants, glycerol, dimethylsulfoxide (DMSO), and dimethylacetamide (DMA), were compared on fowl spermatozoa. The viability and integrity of spermatozoa were measured with eosin-nigrosin smears. Glycerol was the least deleterious cryoprotectant, followed by DMA, and DMSO was the most toxic. Methods employing either glycerol or DMA were then compared for t...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

It is established that cortisone and hydrocortisone may prevent inflammation but their precise mode of action remains unknown. Therefore, it is desirable to examine the histological modifications which these hormones elicit in connective tissue under varied experimental conditions. This investigation has two objectives, the first being to compare the changes which occur in connective tissue sur...

The aim of this study was to systematically compare the degradation of azo dye acid orange 7 by spongy pellets and attached biofilm of Coriolus versicolour (NBRC 9791) in a membrane bioreactor (MBR) under non-sterile conditions. Mild stirring (35 rpm) resulted in spherical (φ=0.5 cm), spongy pellets and concomitantly triggered high enzymatic activity of the fungus, allowing for excellent decolo...