OBJECTIVES To investigate prolapse symptoms and objectively measured pelvic organ prolapse, 12 years after childbirth, and association with delivery mode history. DESIGN Twelve-year longitudinal study. SETTING Maternity units in Aberdeen, Birmingham and Dunedin. POPULATION Women dwelling in the community. METHODS Data from women were collected 12 years after an index birth and women wer...

The use of polypropylene mesh devices for Pelvic Organ Prolapse (POP) spread rapidly during the last decade, yet our knowledge of the mesh-tissue interaction is far from complete. We aimed to perform a thorough pathological examination of explanted POP meshes and describe findings that may explain mechanisms of complications resulting in product excision. We report a spectrum of important findi...

With the aging population in the United States, there has been a renewed interest in pessaries as a conservative alternative to surgical repair for pelvic organ prolapse (POP). They present a good option for patients who have not completed childbearing, do not desire surgery, or are poor surgical candidates. Long-term pessary use is a safe and effective option for patients with POP and stress u...

Pelvic Organ Prolapse (POP) is a major clinical burden affecting 25% of women, with vaginal delivery a major contributing factor. We hypothesised that increasing parity weakens the vagina by altering the extracellular matrix proteins and smooth muscle thereby leading to POP vulnerability. We used a modified POP-quantification (POP-Q) system and a novel pressure sensor to measure vaginal wall we...

OBJECTIVE To investigate whether episiotomy, perineal laceration, and operative delivery are associated with pelvic floor disorders after vaginal childbirth. METHODS This is a planned analysis of data for a cohort study of pelvic floor disorders. Participants who had experienced at least one vaginal birth were recruited 5-10 years after delivery of their first child. Obstetric exposures were ...

PURPOSE We compared sexual function in women with pelvic organ prolapse to that in women without prolapse. MATERIALS AND METHODS We collected sexual function data using a standardized, validated, condition specific questionnaire. The study group consisted of 30 women with pelvic organ prolapse and it was compared with 30 unmatched controls without evidence of prolapse. RESULTS The 2 groups ...

Evidence suggests European American (EA) women have two- to five-fold increased odds of having pelvic organ prolapse (POP) when compared with African American (AA) women. However, the role of genetic ancestry in relation to POP risk is not clear. Here we evaluate the association between genetic ancestry and POP in AA women from the Women's Health Initiative Hormone Therapy trial. Women with gra...

Pelvic organ prolapse (POP) affects millions of women worldwide, and is a health problem for 50% of parous women aged over 50 years (1). Multiple procedures and surgical techniques have been used, with or without the use of vaginal meshes, due to common treatment failure, reoperations, and complication rates in some studies. Randomized trials comparing the use of mesh to native tissue repair in...

Background It is common to see women carrying heavy loads on their back in developing countries including Ethiopia. This may have an effect on pelvic organ prolapse. The objective of this study was to determine prevalence and factors associated with pelvic organ prolapse among pedestrian back-loading women in Bench-MajiZone, 2016. Methods The study was conducted in Bench-MajiZone, Southwest E...