Pituitary adenylate-cyclase activating polypeptide (PACAP) has neuroprotective and axonal guidance functions, but the mechanisms behind such actions remain unclear. Previously we examined effects of PACAP (PACAP38, 1 pmol) injection intracerebroventrically in a mouse model of permanent middle cerebral artery occlusion (PMCAO) along with control saline (0.9% NaCl) injection. Transcriptomic and p...

Shadow generation has been subject to serious investigation in computer graphics, and many clever algorithms have been suggested. However, previous algorithms cannot render high quality soft shadows onto arbitrary, animated objects in real time. Pursuing this goal, we present a new soft shadow algorithm that extends the standard shadow volume algorithm by replacing each shadow quadrilateral wit...

Junctions of fields are known to be susceptible to developing cold or hot spots in the presence of even small geometrical misalignments. Reduction of these dose inhomogeneities can be accomplished through decreasing the dose gradients in the penumbra, but currently it cannot be done for enhanced dynamic wedges (EDW). An MLC-based penumbra softener was developed in the developer mode of TrueBeam...

See related article, pages 2761–2768. Treatment of ischemic stroke is intuitively simple with fast recanalization of blood vessels being the goal. However, this is frequently easier in theory than in practice. That is why there is some optimism in the stroke community regarding novel devices (eg, MERCI retriever system,1,2 Penumbra catheter,3 balloon angioplasty, and so on) for revascularizing ...

Rendering of shadows is a very important ingredient in three-dimensional graphics since they increase the level of realism and provide cues to spatial relationships. Area or volumetric light sources give rise to so called soft shadows, i.e., there is a smooth transition from no shadow to full shadow. For hard shadows, which are generated by point light sources, the transition is abrupt. Since a...

PURPOSE Investigation of a reduced source to target distance to improve organ at risk sparing during stereotactic irradiation (STX). METHODS The authors present a planning study with perfectly target-volume adapted collimator compared with multi-leaf collimator (MLC) at reduced source to virtual isocentre distance (SVID) in contrast to normal source to isocentre distance (SID) for stereotacti...

We present numerical 2D magnetostatic models for sunspot penumbrae consisting of radially aligned field-free gaps in a potential magnetic field, as proposed by Spruit and Scharmer (2006). The shape of the gaps and the field configurations around them are computed consistently from the condition of magnetostatic pressure balance between the gap and the magnetic field. The results show that field...

Context. The magnetic and kinematic properties of the photospheric Evershed flow are relatively well known, but we are still far from a complete understanding of its nature. The evolution of the flow with time, which is mainly due to appearance of velocity packets called Evershed clouds (ECs), may provide information to further constrain its origin. Aims. We undertake a detailed analysis of the...

BACKGROUND AND PURPOSE Unstable clinical course characterizes the first 24 hours after thrombolysis for anterior circulation stroke, including early neurological deterioration (END), a secondary complication consistently predictive of poor outcome. Apart from straightforward causes, such as intracerebral hemorrhage and malignant edema, the mechanism of END remains unclear in the majority of cas...

Objective Whether activation or inhibition of the mTOR pathway is beneficial to ischemic injury remains controversial. It may result from the different reaction of ischemic penumbra and core to modulation of mTOR pathway after cerebral ischemia-reperfusion injury in rats. Methods Longa's middle cerebral artery occlusion (MCAO) method was conducted to induce the focal cerebral ischemia-reperfu...