نتایج جستجو برای: peptidomimetic
تعداد نتایج: 722 فیلتر نتایج به سال:
Our AutoDock-based incremental docking protocol [66], at each incremental step, explores a few rotatable bonds. A small fragment of a large ligand, with a small number of rotatable bonds, is first selected and its rotatable bonds are set active. Only the active rotatable bonds are explored in each docking operation. The fragment is docked to the protein using AutoDock [44,65] and few best-scori...
In this protocol, we report a novel approach for the synthesis of a new class of heterocyclic 1H-1,2,3-triazole-modified peptidomimetic compounds. The process consists of an Ugi four-component condensation reaction of amines, an isocyanide, an aldehyde and acids followed by a Huisgen 1,3-dipolar cycloaddition reaction with an azide group in the presence of a catalytic amount of CuSO4</...
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