Ab stract Klissoura Cave 1 is lo cated in the north east ern edge of the Argive Plain, Peloponnese, at the en trance of the Berbadiotis river gorge. The cave com prises a col lapsed cave cham ber and a rockshelter area. The strati graphic anal y sis and micromorphological study of the sed i ments elu ci dated the main pro cesses in volved in the for ma tion of the site and its depositional his ...

The intravenous injection of LPS rapidly evokes fever. We have hypothesized that its onset is mediated by prostaglandin (PG)E(2) quickly released by Kupffer cells (Kc). LPS, however, does not stimulate PGE(2) production by Kc as rapidly as it induces fever; but complement (C) activated by LPS could be the exciting agent. To test this hypothesis, we injected LPS (2 or 8 microg/kg) or cobra venom...

Cholesterol gallstones occur rarely in childhood and adolescence and increase linearly with age in both genders. To explore whether aging per se increases cholesterol saturation of bile and gallstone prevalence, and to investigate age-related changes in hepatic and biliary lipid metabolism, we studied gallstone-susceptible C57L mice and resistant AKR mice of both genders fed 8 weeks with a lith...

Several studies have found that sleep deprivation reduces the hypercapnic ventilatory response (HCVR). Such results may have been affected by uncontrolled activities or environmental influences during the sleep deprivation period. The current study determined the "pure" effect of sleep deprivation on respiratory control under strictly controlled behavioral and environmental conditions. After 2 ...

Behavioral control over a stressful event reduces the negative consequences of not only that event, but also future stressful events. Plasticity in the prelimbic (PL) medial prefrontal cortex is critical to this process, but the nature of the changes induced is unknown. We used patch-clamp recording to measure the intrinsic excitability of PL pyramidal neurons in acute slices from rats exposed ...

The ability of hyperglycemia per se to suppress endogenous glucose production (GP) is blunted in type 2 diabetes. This could be due in part to decreased glucose-induced flux through glucokinase (GK). Because fructose activates hepatic GK, we examined whether catalytic amounts of fructose could restore inhibition of GP by hyperglycemia in humans with type 2 diabetes. Glucose fluxes ([3-(3)H]gluc...