The data reported in Nicolle et al. [30] suggest a preservation of three hippocampal synaptic proteins (synaptophysin, synaptotagmin, and synaptosomal associated protein-25) in old, memory-deficient rats. These are interesting and important data, which, at first consideration, seem to raise a question about whether alterations of synaptic connectivity can contribute in a substantial way to the ...

We have previously shown that hippocampal long-term potentiation (LTP), one form of synaptic plasticity that may underlie learning and memory, is attenuated by blocking neuron activity of the basolateral amygdala (BLA). In the present study we investigated the amygdala noradrenergic or cholinergic contribution to hippocampal LTP formation. When propranolol, a beta-adrenoceptor antagonist, was i...

We describe a simple method, using readily available minaturised components, for inducing and monitoring long-term potentiation (LTP) at perforant path-granule cell synapses in the dentate gyrus of the freely moving mouse. Tetanic stimulation induced LTP of the field EPSP and the population spike which persisted for more than 24 h but was not present 10 days after the tetanus. The potentiation ...