Introduction/Objective. The objective of the study was to determine difference in peripapillary retinal nerve fiber layer (RNFL) thickness patients with open-angle glaucoma (POAG) comparison healthy population and according progression disease. Methods. Four groups were formed among 120 patients: group without glaucoma, early, moderate POAG, preperimetric group. Visual field optical coherent to...

PURPOSE We aimed to characterize alterations in the posterior scleral collagen microstructure before detectable disease onset in a canine model of open-angle glaucoma caused by an ADAMTS10 mutation. METHODS Collagen orientation, anisotropy degree (proportion of preferentially aligned collagen), and relative density were measured at 0.4 mm spatial resolution using synchrotron wide-angle X-ray ...

PURPOSE Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thicknes...

PURPOSE Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON). METHODS This three-year cohort study was conducted fro...

PURPOSE To evaluate intrasession and between-visit reproducibility of sector peripapillary angioflow vessel-density (PAFD, %) values in the optic nerve head (ONH) and radial peripapillary capillaries (RPC) layers, respectively, and to analyze the influence of the corresponding sector retinal nerve fiber layer thickness (RNFLT) on the results. METHODS High quality images acquired with the Angi...

PURPOSE To measure the change in peripapillary retinal blood flow in response to hyperoxia by using optical coherence tomography (OCT) angiography. METHODS One eye of each healthy human participants (six) was scanned with a commercial high-speed (70 kHz) spectral OCT. Scans were captured twice after 10-minute exposures to normal breathing (baseline) and hyperoxia. Blood flow was detected by t...

PURPOSE Though there are many reports regarding the structure-function relationship in glaucoma, they are too complicated to apply to the routine clinical setting. The aim of this study was to investigate the direct relationship between peripapillary retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and visual field (VF) severity indices computed by stand...

PURPOSE This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal eyes from 84 subjects of AD and ED were manually delineated to identify the pr...

BACKGROUND The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. METHODS A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included....

Many reports of colobomata of the choroid, involving the peripheral choroid, are available in the literature, but no case of a localized congenital choroidal defect in the peripapillary region has bcen reported. A case of such colobomata present on both sides is reported here which, since coming under observation I0 years ago, has presented a considerable diagnostic problem to different ophthal...