Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells. Objective: To investigate the cytotoxic and immunomodulatory properties of Arteether in-vivo and in-vitro. Methods: In this study, we ...

Cell Therapy For Therapeutic Vascularization Endothelial Progenitor Cells and Postnatal Vasculogenesis: Experimental Evidence The option of performing full-scale endothelial cell transplantation to optimize local neovascularization is daunting if even feasible. An alternative, attractive strategy is designed to exploit the conceptual notion that endothelial cells and hematopoietic stem cells we...

Aims: The current study aimed to evaluate the genotoxicity of Vaishvanara Churna, a polyherbal formulation by using Peripheral Blood Mononuclear Cells. was supported content heavy metals in ayurvedic formulation. Background: Churna is classical that used for treating conditions, such as flatulence with gurgling sound (Adhmana), abdominal lump (Gulma); Duodenal ulcer (Parinamasula), Rheumatism (...

Focal segmental glomerulosclerosis (FSGS) is a major cause of familial nephrotic syndrome. We generated 20 induced pluripotent stem cell lines from patients diagnosed with FSGS. The iPSC include 8 female and 12 male cover donor age range 31 to 78. were peripheral blood mononuclear cells by integration-free reprogramming using Sendai virus vectors. Cell fully characterized regarding their plurip...

Objective: The aim of this study is to observe the homing and distribution of the foreign multidrug resistance gene 1 (mdr1) in gene therapy. Method: After the bone marrow mononuclear cells of male BABL/C which was transferred with retrovirus-mediated mdr1 were transplanted into female Babl/c which was conducted radiotherapy with 60Co-γ, the expression and distribution of foreign mdr1 in the bo...

Background: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. Objectives: To evaluate the effect of mTOR inhibition, using rapamycin on the proliferation and apoptosis of cord blood mononuclear cells, as well ...

glioblastoma multiforme and other malignant gliomas continue to be associated with a dismal prognosis despite advances in diagnosis and therapy.1,2 Mean survival from the time of diagnosis is less than one year in most cases. This has spurred investigation of new treatment modalities such as immunogene ABSTRACT: Background: Cancer immunogene therapy is based on vaccination with radiated, autolo...

BACKGROUND Interstitial lung diseases are characterised by the recruitment of mononuclear cells to disease sites where maturation occurs and activation products, including lysozyme (LZM), are released. Analysis of in vitro cell culture supernatants for activation products masks the functional heterogeneity of cell populations. It is therefore necessary to examine the secretion of activation pro...

The use of marrow aspirates in bone marrow transplantation. clinical evaluation. and experimental studies has prompted the present study of the functional characteristics of mononuclear cells from aspirated (iliac crest) and curettaged (rib) marrow. In this manner. the relative contribution of peripheral blood contamination of aspirated bone marrow cells in investigating and understanding marro...