Peripheral nerve injury is a debilitating condition for which new bioengineering solutions are needed. Autografting, the gold standard in treatment, involves sacrifice of a healthy nerve and results in loss of sensation or function at the donor site. One alternative solution to autografting is to use a nerve guide conduit designed to physically guide the nerve as it regenerates across the injur...

Objective: Peripheral nerve transection causes neuonal cell death. Effects of surgical nerve repair on survival of primary sensory neurons was to be studied. Methodology: This is a morphometeric study of dorsal root ganglion neurons of adult rats by Hoechst staining conducted at Neuroscience laboratory and Cellular and Molecular Center, Medical faculty, Iran University of Medical Sciences. Mode...

Peripheral nerve injuries are commonly seen as a result of domestic, industrial, or military trauma. Sharp objects usually cause these nerve injuries. When assessing these injuries, it is important to evaluate each nerves' motor and sensory function. One must be cognizant of associated injuries such as fractures, vascular damage, and musculotendinous lacerations. The time since the injury, leve...

BACKGROUND Sciatic nerve injuries often cause partial or total loss of motor, sensory and autonomic functions due to the axon discontinuity, degeneration, and eventual death which finally result in substantial functional loss and decreased quality of life. Nerve growth factor (NGF) plays a critical role in peripheral nerve regeneration. However, the lack of efficient NGF delivery approach limit...

INTRODUCTION Dexamethasone and vitamin B(12) are currently used in the clinic to treat peripheral nerve damage but their mechanisms of action remain incompletely understood. In this study we hypothesized that dexamethasone and vitamin B(12) promote the production of endogenous neurotrophic factors, thereby enhancing peripheral nerve repair. MATERIAL AND METHODS Ninety-six adult male Wistar ra...

Currently, surgical treatments for peripheral nerve injury are less than satisfactory. The gold standard of treatment for peripheral nerve gaps >5 mm is the autologous nerve graft; however, this treatment is associated with a variety of clinical complications, such as donor site morbidity, limited availability, nerve site mismatch, and the formation of neuromas. Despite many recent advances in ...

BUMC PROCEEDINGS 2003;16:152–156 Some nerve injuries require repair in order to regain sensory or motor function. Although this article focuses primarily on trigeminal nerve (TN) injuries and repairs, the facts presented may apply to any peripheral nerve repair. The primary indications for nerve repair or grafting are 1) an injury or continuity defect in a nerve, as a result of trauma, patholog...

Multiple-bud regeneration, i.e., multiple amplification, has been shown to exist in peripheral nerve regeneration. Multiple buds grow towards the distal nerve stump during proximal nerve fiber regeneration. Our previous studies have verified the limit and validity of multiple amplification of peripheral nerve regeneration using small gap sleeve bridging of small donor nerves to repair large rec...

Lower extremity peripheral nerve injuries can be highly morbid to patients and challenging problems for reconstructive surgeons manage. Nerve transfers have recently emerged as a promising technique in the treatment of these injuries. The nerve-transfer paradigm is predicated on use an expendable, unaffected donor axons restore motor or sensory function target end organ. Distal close organ may ...