BACKGROUND Though success rates of endodontic initial treatment have been improving over the years, persistence of periapical disease is far from being a rare condition. The most common therapeutical options for the re-treatment of teeth with periapical pathosis are non-surgical orthograde treatment and surgical treatment. Selection between alternative treatments should be based on assessment o...

We examined soft tissue biopsies from 26 patients with symptomatic nerve root fibrosis and arachnoiditis after a previous laminectomy. Dense fibrous connective tissue was found about the nerve roots and in 14 cases (55%) fibrillar foreign material was seen within it. This material had the histochemical characteristics of cotton fibres from swabs and neurosurgical patties. In two other cases ner...

Root perforations may occur due to pathological processes or treatment consequences. Such perforations are severe complications and are associated with dramatically compromised endodontic treatment outcomes, especially when bacterial infection is allowed to establish and if the seal between the endodontic space and periradicular tissue is not provided. A new known material, mineral trioxide agg...

A comprehensive understanding of tooth development, etiology, and pathogenesis of pulp and periradicular tissues supports the underlying principles for endodontic treatment. Innovative therapies apply biological modulators that have been identified during tooth and bone embryogenesis and later became cloned for experimental and clinical application. These modulators are intended to improve trea...

Material and Methods: Children as dental patients, a study The records of 100 children between age 2-10 years visiting a pediatric dental clinic for various pulpal and periapical conditions were evaluated. A total of 364 procedures (pulp therapies such as pulpotomy and pulpectomy, and extractions) were carried out in the children for different pulpal and periapical pathologies (irreversible pul...

Pulpal and periradicular pathosis are the result of microbial, mechanical, or chemical invasion. Microorganisms are the main irritants of pulpal and periapical tissues. The goal of the obturation is to obtain a fluid-tight seal of the root canal system from its coronal aspect through its apical extent to preserve from the irritants.. Root apices have morphological irregularities in teeth with p...

Mineral trioxide aggregate (MTA) has been shown to possess excellent sealing ability when tested with dye, bacteria, and a fluid filtration technique. Endotoxin, a component of the cell wall of Gram-negative bacteria, has been proposed to play a role in the pathogenesis of periradicular lesions. This study used a modified Limulus Amebocyte Lysate test for the presence of endotoxin as a tracer a...

Large periapical defects may adversely affect the success rate of endodontic surgery. Use of regenerative therapy may enhance the prognosis of such teeth. A case of traumatized upper anterior teeth with infected radicular cyst and associated sinus tract reported to the dental hospital. A periradicular surgical procedure was performed to remove the nonhealing pathological tissue. To augment the ...