Cyclizine (1-benzhydryl-4-methyl-piperazine, CAS 82-92-8, CYC, I), a piperazine derivative, belongs to H1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other H1-receptor antagonists. In this study, two new tolyl and cumene derivatives of I (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

background: cellulite is the accumulation of subcutaneous fat and connective tissue in tights and buttocks. xanthines, such as aminophylline, are used as phosphodiesterase inhibitors, and are also adenosine receptor antagonists. objectives: the aim of the present study was to characterize in vitro aminophylline transdermal absorption through shed snake skin, and to investigate the absorption en...

background: development of biodegradable and biocompatible films based on protein polymer with strong antioxidant and antibacterial activities has gradually obtained extensive concern in the world. in this study, the improvement of gelatin film properties incorporated with ferula assa-foetida essential oil (fao) as a potential antioxidant/antibacterial wound dressing film was investigated. mate...

background and objectives: kefiran (kef) is a water-soluble polysaccharide that can form transparent film however, it is brittle. therefore, in order to improve the mechanical properties of kefiran film, a mixture with other polymers can be offered. the expansion of mixed systems can propose kefiran and polyvinyl alcohol (pvoh) as a new composite film. materials and methods: solutions of 20 gra...

in this paper effect of sio 2 nanoparticles was investigated on potato starch films. potato starch films were prepared by casting method with addition of nano-silicon dioxide and a mixture of sorbitol/glycerol (weight ratio of 3 to 1) as plasticizers. sio 2 nanoparticles incorporated to the potato starch films at different concentrations 0, 1, 2, 3, and 5% of total solid, and the films were dri...

Methods which can be used to assess the chloride permeability of various types of concrete in a relatively short time are described. An electrical potential from 60-80 volt DC is applied either between a chloride solution ponded on a slab surface and the top of rebar mat, or between two faces at a core taken from a structure. The amount of chloride and sum of the electrical current which passes...

This study was planned to explore the capability of nanoemulsions (NEs) consisting of CapryolTM 90 and oleic acid for the delivery of rapamycin (RAP). Permeability and cytotoxicity of RAP-loaded NEs were also inspected. Pseudo-ternary phase diagrams were created with oleic acid and CapryolTM 90 (as oil phase) and four surfactants and co-surfactants at various weight ratios (Rsm). Selected NEs f...

this paper proposes a two-step approach for characterizing the reservoir properties of the world’s largest non-associated gas reservoir. this approach integrates geological and petrophysical data and compares them with the field performance analysis to achieve a practical electrofacies clustering. porosity and permeability prediction is done on the basis of linear functions, succeeding the elec...

This study was planned to explore the capability of nanoemulsions (NEs) consisting of CapryolTM 90 and oleic acid for the delivery of rapamycin (RAP). Permeability and cytotoxicity of RAP-loaded NEs were also inspected. Pseudo-ternary phase diagrams were created with oleic acid and CapryolTM 90 (as oil phase) and four surfactants and co-surfactants at various weight ratios (Rsm). Selected NEs f...