AIMS To investigate the clinical picture and frequency of Bordetella pertussis and B parapertussis infections after introduction of acellular pertussis (acP) vaccines in Germany. METHODS Prospective surveillance for B pertussis and B parapertussis in 14 144 toddlers. Pertussis vaccination coverage was 86%, either with acP (75%) or whole cell pertussis (wcP) vaccine (11%). All children present...

In 2005, two tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines were licensed and recommended for use in adults and adolescents in the United States: ADACEL (sanofi pasteur, Swiftwater, Pennsylvania), which is licensed for use in persons aged 11--64 years, and BOOSTRIX (GlaxoSmithKline Biologicals, Rixensart, Belgium), which is licensed for use in persons aged 10...

OBJECTIVE To evaluate the immunogenicity and reactogenicity of an acellular pertussis vaccine (pa) either formulated with diphtheria and tetanus toxoids (dTpa) or administered consecutively with a licensed tetanus and diphtheria vaccine (Td) as a 5th dose in adolescents. METHODS A total of 510 healthy children 10 to 13 years of age were assigned randomly, using a single-blind design, to recei...

Pertussis is the only disease for which children are routinely vaccinated that is not at historically low levels in the United States. The increases seen in pertussis are not due to ineffective vaccines or programs. The effectiveness of acellular per-tussis vaccine has been demonstrated to be high in both prelicensure studies and postlicensure evaluations, and coverage among vaccine-eligible ag...

BACKGROUND Whooping cough is a respiratory disease caused by Bordetella pertussis, which induces mucosal IgA antibodies that appear to be relevant in protection. Serum IgA responses are measured after pertussis infection and might provide an additional role in pertussis diagnostics. However, the possible interfering role for pertussis vaccinations in the induction of serum IgA antibodies is lar...

Hypotonic-hyporesponsive episode (HHE), sometimes called the ragdoll, collapse reaction, or shock-like state refers to an adverse event occurring after administration of whole-cell pertussis vaccine; the infant becomes pale and displays decreased responsiveness, muscle tone, and activity. Although HHE occurs most often after immunization with whole-cell pertussis vaccine, it has also been repor...

Previously controlled vaccine preventable diseases (VPDs) are in resurgence. To date, there have been 477 confirmed measles cases in the United States in 2014, the most in 18 years. In 2013 there were ∼25 000 pertussis cases in the United States. Vaccine refusal has been associated with outbreaks of invasive Haemophilus influenzae type b disease, varicella, pneumococcal disease, measles, and pe...

Immunization with acellular pertussis vaccine (aP) induces higher specific antibody levels and fewer adverse reactions than does immunization with the whole-cell vaccine (wP). However, antibody levels in infants induced by both types of pertussis vaccines wane already after 1 year. Therefore, long-term T-cell responses upon vaccination might play a role in protection against pertussis. In a cro...

BACKGROUND Despite widespread childhood vaccination against Bordetella pertussis, disease remains prevalent. It has been suggested that acellular vaccine may be less effective than previously believed. During a large outbreak, we examined the incidence of pertussis and effectiveness of vaccination in a well-vaccinated, well-defined community. METHODS Our center provides care to 135 000 patien...