Astragalus extract mixture HT042 is a standardized multiherbal mixture comprising Astragalus membranaceus, Eleutherococcus senticosus, and Phlomis umbrosa, which has proven to promote children's height growth. The aim of this study was to investigate the effects of HT042 on longitudinal bone growth, bone mass, and bone microstructure in growing rats using a high-resolution microcomputed tomogra...

This study was designed to investigate the anti-inflammatory and anti-nociceptive activity of the methanol extract from the aerial part of Phlomis younghusbandii (MEAP) and to explore the possible related mechanisms. Anti-inflammatory effects of MEAP were evaluated by using the ear edema test induced by dimethylbenzene and vascular permeability test induced by acetic acid. Anti-nociceptive acti...

Hormone replacement therapy (HRT) consists of highly effective prescription medications for treating menopausal symptoms; however, these agents have exhibited side effects including the risk of estrogen-induced carcinogenesis. Therefore, interest in phytotherapy-based materials as a natural source of alternatives to estrogen therapy has increased. However, some of these herbal medicines have be...

The majority of de novo structural chromosome aberrations in fetuses and newborns are considered being of cells of mammals for DNA damage during gametogenesis. 4617 chromosomal studies performed during 19 years (from 1992 to 2011), at Hospital Para El Niño Poblano in México, a total of 1596 patients showe positive for DNA aberrations. Among these studies population, 0.23% (11) chromosome transl...

Background and objectives: Phlomis bruguieri Desf. (Lamiaceae) is a perennial herbaceous plant distributed in Iran, Turkey and Iraq. Despite medicinal potentials of this species, the current knowledge on its phytochemical constituents is limited. The aim of the present study was to investigate the phytochemical constituents of the essential oil and various extracts of this species. Methods: Ess...

Imperatorin (IMT) is a furanocoumarin from the root of Phlomis younghusbandii (Lamiaceae) with various activities. In the present study, the anti‑inflammatory effects of IMT were evaluated by examining dimethylbenzene‑induced ear edema, acetic acid‑induced vascular permeability and by performing cotton pellet granuloma assessments in mice. In addition, the expression of pro‑inflammatory cytokin...

OBJECTIVE This review focuses on the medicinal plants growing and having history of folk medicine in Iran and found effective as anti free radical damage in animal or human. DESIGN Embase, Scopus, Pubmed, Web of Science, Google Scholar, IranMedex, and SID databases were searched up to 2 February 2008. The search terms were antioxidant or "lipid peroxidation" and "plant, medicinal plant, herb,...