نتایج جستجو برای: phosphatases
تعداد نتایج: 7697 فیلتر نتایج به سال:
Signal transduction in eukaryotes is generally transmitted through phosphorylation cascades that involve a complex interplay of transmembrane receptors, protein kinases, phosphatases and their targets. Our previous work indicated that bacterial protein-tyrosine kinases and phosphatases may exhibit similar properties, since they act on many different substrates. To capture the complexity of this...
An oncogenic retrovirus, human T-cell leukemia virus type I (HTLV-I), encodes an oncoprotein, Tax, which plays critical roles in leukemogenesis of adult T-cell leukemia/lymphoma (ATLL) through the pleiotropic actions such as transcriptional regulation, cell cycle control, and transformation. We have previously reported that PTEN and SHIP- 1, PIP3 inositol phosphatases that negatively regulate t...
beta-Adrenoceptor stimulation acts in the heart in part by increasing the phosphorylation state of phospholamban and phospholemman. There is evidence that the beta-adrenoceptor-mediated increase in phospholamban phosphorylation is in part due to inhibition of type 1 phosphatases. The aim of the present study was to elucidate which phosphatases dephosphorylate phospholamban and phospholemman in ...
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