Deformation of surface-adsorbed liposomes is an important parameter that governs the kinetics of their transformations, but one that is very difficult to measure in the case of nm-size liposomes. We investigate the deformation of dimyristoyl phosphatidyl choline liposomes by quartz crystal microbalance (QCM) as a function of temperature and show that it follows the dependence of this lipid's be...

Filipin at low concentrations rapidly hemolyzes bovine erythrocytes. Of the compounds tested, which were known a constituents of cell membranes, only cholesterol and phosphatidyl-choline prevented hemolysis. A specific complex was formed only with cholesterol. Filipin treatment caused a release of cholesterol from erythrocytes. Since all cell sterol is located in the cell membrane, the hemolyti...

I. Phospholipds were studied in the heart muscles, skeletal muscles and livers of scven Ayrshire calves which received vitamin E-free maize 011 (in filled milk) VTith and without supplementary a-tocopherol from I week old for 17 d. The calves that were not given vitamin F: developed muscular dystrophy. 2. Decreased amounts of cardiolipin and increased amounts of sphlngomyelin were found in the ...

Phospholipids are essential components of all biological membranes. Phosphatidylcholine (PC) and Phosphatidylserine (PS) are Phosphatidyl-phospholipids that are required for normal cellular structure and function. The participation in physical activity often challenges a variety of physiological systems; consequently, the ability to maintain normal cellular function during activity can determin...

Five new bifunctional conjugates of pyropheophorbide a with 17-substituted testosterone, dihydrotestosterone and epitestosterone differing in the length linker (1 � 5) two complex 6 7 (containing three functional units: a, 17?-substituted lipophylic hexadecyl chain, connected L-lysine joining block) were synthesized. Mutual influence steroidal macrocyclic fragments 7) was established by analysi...

Neurotransmitters activate a phospholipase D that is though to specifically hydrolyse phosphatidylcholine. This enzyme has a unique property known as transphosphatidylation: in the presence of an appropriate nucleophilic receptor such as an alcohol, phospholipase D will catalyse the production of phosphatidyl-alcohol. We have studied phospholipase D using an in vitro assay that uses [3H]butanol...

In 1980, two exceptional scientists met for the first time when they were both working at the Karolinska Institutet. Tore Curstedt and Bengt Robertson began their extraordinarily successful and long-lasting collaboration to develop a high-quality surfactant preparation, which could be produced in a reproducible way in large quantiTore Curstedt was born as an only child in 1946 in Piteå, a small...