Acute inflammatory responses to invading bacteria such as Staphylococcus aureus include mobilization of polymorphonuclear leukocytes (PMN) and extracellular group IIA phospholipase A2 (gIIA-PLA2). Although accumulating coincidentally, the in vitro anti-staphylococcal activities of PMN and gIIA-PLA2 have thus far been studied separately. We now show that degradation of S. aureus phospholipids du...

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Lysolecithin is preferentially used in food technology, in animal feed products, and in cosmetics and pharmaceutical preparations as a surfactant.i} Industrially, lysolecithin s produced by enzymatic hydrolysis of Iecithin, The most eommon enzyme used is pancreatin prepared from porcine pancreas. However, the use of pancreatin has certain disadvantages, such as its limited supply, its high cost...

Apolipoprotein CIII (apo CIII), a small glycoprotein that binds to the surfaces of certain lipoproteins, is associated with inflammatory and atherogenic responses in vascular cells. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been proposed as an inflammatory biomarker and potential therapeutic target for cardiovascular disease (CVD). Here, we report that apo CIII increases Lp-PLA2 mRN...

Abstract The regulation of the activity and selectivity phospholipase A2 (PLA2), which is capable cleaving fatty acid in second position ( sn-2 ) phospholipid, carried out through membrane-binding catalytic sites enzyme. For hydrolytic activity, PLA2 must first bind to phospholipid membrane, binding efficiency depends on composition membrane. site formed by several tens amino acids its differs ...

Activation of phospholipase A2(PLA2) and accumulation of lysophosphatidylcholine contribute importantly to arrhythmogenesis during acute myocardial ischemia. We examined thrombin stimulation of PLA2 activity in isolated ventricular myocytes. Basal and thrombin-stimulated cardiac myocyte PLA2 activity demonstrated a distinct preference for sn-1 ether-linked phospholipids with arachidonate esteri...

Objective(s): The effects of alpha linolenic acid (ALA) on tracheal responsiveness (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), interleukin 4 (IL-4), interferon gamma (INF-γ) level and INF-γ/IL4 ratio in bronchoalveolar lavage fluid (BALF) of sensitized rats were examined.Materials and Methods: TR to methacholine and ovalbumin (OA), BALF levels of TP, PLA2 and IgE ...

Abstract Background Chronic hepatitis C virus (HCV) infection has been linked to cardiovascular disease (CVD). However, CVD risk prediction in chronic HCV-infected patients is problematic as the prevalence of different cardiac biomarkers these currently unknown. Serum lipids, which are routinely used traditional scores, may underestimate patients, while non-hepatically produced biomarkers, incl...

Eight naturally occurring marine-sponge derived sesquiterpenoid quinones were evaluated as potential inhibitors of pyruvate phosphate dikinase (PPDK), a C4 plant regulatory enzyme. Of these, the hydroxyquinones ilimaquinone, ethylsmenoquinone and smenoquinone inhibited PPDK activity with IC50's (reported with 95% confidence intervals) of 285.4 (256.4-317.7), 316.2 (279.2-358.1) and 556.0 (505.9...

Terry, Christi M., Jennifer A. Clikeman, John R. Hoidal, and Karleen S. Callahan. TNF-a and IL-1a induce heme oxygenase-1 via protein kinase C, Ca21, and phospholipase A2 in endothelial cells. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1493–H1501, 1999.—Heme oxygenase-1 (HO-1), an enzyme important in protection against oxidant stress, is induced in human vascular endothelial cells by the c...