patients with malignancy are at higher risk of thrombotic complications due to the hypercoagulability state. our objective in this study was to assess the serum concentrations of homocysteine, anti phospholipid antibodies, and anti cardiolipin in patients with benign and malignant breast tumors and study the effect of chemotherapy on the serum levels of these markers. a case control study was c...

Endoplasmic Reticulum (ER) is the largest and one of most complex cellular structures, indicating its widespread importance variety functions, including synthesis membrane secreted proteins, protein folding, calcium storage, lipid biogenesis. Moreover, ER implicated in cholesterol, plasmalogen, phospholipid, sphingomyelin biosynthesis. Furthermore, contact with organelles, such as mitochondria,...

The interactions of mono-rhamnolipids (mono-RLs) with model membranes were investigated through a biomimetic approach using phospholipid-based liposomes immobilized on gold substrate and also by the multiparametric surface plasmon resonance (MP-SPR) technique. Biotinylated bound onto an SPR chip coated streptavidin layer. resulting MP-SPR signal proved efficient binding liposomes. thickness lip...

This review deals with the in vitro biosynthesis of the characteristics of polar lipids in archaea along with preceding in vivo studies. Isoprenoid chains are synthesized through the classical mevalonate pathway, as in eucarya, with minor modifications in some archaeal species. Most enzymes involved in the pathway have been identified enzymatically and/or genomically. Three of the relevant enzy...

This study shows that phospholipid depletion has a major impact on the size and structure of spherical, reconstituted high density lipoproteins (rHDL) and their remodeling by cholesteryl ester transfer protein (CETP). Spherical rHDL, 9.2 nm in diameter with a phospholipid/cholesteryl ester/unesterified cholesterol/apolipoprotein A-I (apoA-I) (PL/CE/UC/A-I) molar ratio of 37.3/24.5/4.1/1.0, were...

Hevesy (1,Z) and Artom (3) have inferred from studies on the incorporation of labeled inorganic phosphate into phospholipid that plasma phospholipid is formed largely in the liver. This inference was based on a comparison of the specific activities of phospholipid phosphorus of plasma with those of other organs. Similar observations have been made in this laboratory (Table I). The phospholipid ...

Mitochondria and microsomal membranes were prepared from normal, fetal, and regenerating rat liver and from seven Morris hepatomas of varying growth rates and analyzed for percentage of phospholipid composition and phospholipid con tent per mg protein. The Morris hepatomas studied included the7777,5132tc,7800,7794A,7787,9633,and 96i8A. Cardiolipin is localized in mitochondria in all tissues stu...

The inhibition of phospholipid synthesis engendered by starving glycerol 3-phosphate (G3P) auxotrophs of Escherichia coli (plsB or gpsA) for G3P is incomplete; 5 to 10% of the normal rate of phospholipid synthesis remains, even after prolonged starvation. We report that G3P starvation of a strain having lesions in both the gpsA and plsB genes resulted in essentially complete (greater than 98.5%...

Shape transformations and budding of phospholipid/fatty acid giant vesicles can be induced by an internal chemical stimulus (pH change) when coupled with osmotic shock. A kinetic model the ADE theory help to clarify mechanism.

An unusual micelle was discovered in mixtures of the nonionic detergent octaethyleneglycol-mono-n-dodecylether with disaturated phospholipids such as 1,2-dimyristoyl-sn-glycero-3-phosphocholine or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine in water. These mixtures undergo a structural transition upon cooling through the chain-melting temperatures of the respective phospholipids, resulting in t...