The synthesis of spirocyclic amide acetals (33–93 %) has been achieved through Ru(II)-catalyzed condensations N-carbamate protected pyrrolidinones with metal carbenes derived from α-diazo-β-ketoesters. Thanks to the mildness diazo decomposition conditions induced by a 1 : combination [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, formation sensitive products is possible. Full characterization thi...

Abstract Versatile, two-step syntheses of dihydrodibenzo[c,e]azepines, carbazole derivatives, and other alkaloid-type drug-like scaffolds by in situ generated azomethine ylide-induced intramolecular electrocyclization reaction from commercially available materials are presented. The mechanisms transition-metal-free carbon–carbon bond formation the role kinetic control, resulting good regioselec...

The Rh(II)-catalyzed coupling of chiral 2-thiopyranylindoles with vinyl diazoacetates results in the generation of indolines having quaternary substitution at C3 in high diastereoselectivity.

Using a common 1-(1-phenylethenyl)-1,2,3,4-tetrahydroisoquinoline precursor to the required ylide or N-oxide intermediate, the Stevens [2,3] and analogous Meisenheimer [2,3] sigmatropic rearrangements have been applied to afford concise syntheses of phenyl -substituted representatives of each of the reduced 1H-3-benzazonine and 4,3-benzoxazonine systems, respectively. Single crystal X-ray struc...

The MetalJet X-ray source provides indium K α radiation with a wavelength even shorter than Ag radiation. This paper reports on problematic spectral impurities and presents possible countermeasures so that collection of data excellent quality up to high resolution is possible. It demonstrated these can be used in the refinement multipole model, results which are for topological analysis assess ...

The importance of chiral epoxides as synthetic building blocks in asymmetric synthesis is extremely difficult to overstate. While the highly enantioselective Sharpless, and JacobsenKatsuki, protocols for the epoxidation of internal alkenes are nowmature technologies of inestimable value, the conversion of terminal alkenes to enantioenriched 1-oxiranes has proven a considerably more difficult pr...