Protein kinases enable cellular information processing. Although numerous human phosphorylation sites and their dynamics have been characterized, the evolutionary history and physiological importance of many signaling events remain unknown. Using target phosphoproteomes determined with a similar experimental and computational pipeline, we investigated the conservation of human phosphorylation e...

During recent studies of oxidative phosphorylation in rat liver mitochondria (2, 3)) we observed that preparations isolated with meticulous care catalyzed a significant uptake of inorganic orthophosphate in the absence of any added substrate. Although incidental observations of endogenous activity of isolated mitochondria have been noted by others (P9), no extensive study of this phenomenon has...

Prostate cancer is hormone-dependent and the androgen receptor (AR) involved in its development. AR a transcription factor that activated by ligand binding, result translocation into nucleus, where it initiates gene transcription. In an inactive state cytoplasm exists as complex with heat shock protein 90 (HSP90) some other proteins. When agonist binds, conformational change occurs, resulting H...