Abstract Background Chlorin e6 trisodium salt (Ce6) is a newly developed hydrophilic photosensitizer designed to mediate anticancer photodynamic therapy (PDT). The response of different cancer types and strategies boost efficiency Ce6-PDT are poorly studied. Objectives This study aimed investigate the Ce6-PDT, identify unresponsive ones, develop nanosystem for enhancement. Methods Sk-Br-3, MCF-...

Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 adenocarcinoma cell line was used as a model to study CNPs. demonstrated in primary neutrophils macrophages. Results: Near infrared-activated CNPs elicited rapid death, characterized by elevation...

In 1996, the Scientific Committee on Cosmetology of DGXXIV of the European Commission asked the European Centre for the Validation of Alternative Methods to test eight UV filter chemicals from the 1995 edition of Annex VII of Directive 76/768/EEC in a blind trial in the in vitro 3T3 cell neutral red uptake phototoxicity (3T3 NRU PT) test, which had been scientifically validated between 1992 and...

The use of bioluminescent reporters in neuroscience research continues to grow at a rapid pace as their applications and unique advantages over conventional fluorescent reporters become more appreciated. Here, we describe practical methods and principles for detecting and imaging bioluminescence from live cells and animals. We systematically tested various components of our conventional fluores...