نتایج جستجو برای: phthalazine
تعداد نتایج: 192 فیلتر نتایج به سال:
In continuation of our endeavor with respect to the development of potent and effective isatin-based anticancer agents, we adopted the molecular hybridization approach to design and synthesize four different sets of isatin-quinazoline (6a-f and 7a-e)/phthalazine (8a-f)/quinoxaline (9a-f) hybrids. The antiproliferative activity of the target hybrids was assessed towards HT-29 (colon), ZR-75 (bre...
Recently we have reported a 13C n.m.r. investigation on the site of protonation in the diazanaphthalenes.' This group of N-heterocycles consists of ten compounds: cinnoline (1,2-diazanaphthalene, l), quinazoline (1,3-diazanaphthalene, 2), quinoxaline (1,4-diazanaphthalene, 3), 1 ,5-naphthyridine (1,5diazanaphthalene,4), 1,6-naphthyridine (1,6-diazanaphthalene, 3, 1,7-naphthyridine (1,7-diazanap...
We report preclinical proof of principle for effective treatment of B-precursor acute lymphoblastic leukemia (ALL) by targeting the spleen tyrosine kinase (SYK)-dependent antiapoptotic blast cell survival machinery with a unique nanoscale pharmaceutical composition. This nanoscale liposomal formulation (NLF) contains the pentapeptide mimic 1,4-Bis (9-O dihydroquinidinyl) phthalazine/hydroquinid...
aza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. this contribution describes an electrochemical approach for the preparation of nanosized particles of phthalazine in high yields and very short reaction time. the method is ba...
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