The cholinergic system has been proposed to participate in the development of dependence on opioids. The present study examined effects of dermal pretreatment with methyl parathion (MP), an acetylcholinesterase inhibitor, on the development of physical dependence on morphine. Opioid dependence was induced by continuous intracerebroventricular (i.c.v.) infusion of morphine (26 nmol/μl/h) for 3 d...

Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and exploration of new fields of their applications are at the forefront of modern nanotechnology. The possibility of engineering water-soluble NPs has paved the way to their use in various basic and applied biomedical researches. At present, NPs are used in diagnosis for imaging of numerous molecular mark...

Simultaneous Quantitative Assessment of Morphine Tolerance and Physical Dependence. E. LEONG WAY, HORACE H. LOB AND Fu-H5IUNG SHEN 1 Effects of Analgesics and Other Drugs on Mice in Phenylquinone and Rotarod Tests. JACK PEARL, HERBERT STANDER AND DONNA B. MCKEAN 9 Effects of Halothane upon Auditory Recovery Functions in Cats. LUKE M. KITAHATA, Y05HIKUNI AMAKATA AND ROBERT GALAMBOS 14 Effects of...

results the χ2 test showed that the experimental and control groups significantly differed in relapse rates (χ2 = 6.30, df = 1, p < 0.001). in addition, the covariance analysis showed a significant difference between the two groups in resiliency enhancement at post-test (f = 33.76, p < 0.001) and follow-up (f = 37.67, p < 0.001). conclusion the results indicate that lifestyle training is effect...

Identifying modifiable behaviors associated with prevention of activities of daily living (ADL) impairments is vital to implement preventive strategies for independent living in elderly. We aimed to examine the associations between objectively measured breaks in sedentary time with ADL impairments and physical independence. Cross-sectional assessments were carried out in 371 participants (131 m...