Four E-prostanoid (EP) receptors, designated EP(1), EP(2), EP(3), and EP(4), mediate the cellular effects of prostaglandin E(2) (PGE(2)). The present studies pharmacologically characterize the vasopressor and vasodepressor EP receptors in wild-type mice (EP(2)(+/+) mice) and mice with targeted disruption of the EP(2) receptor (EP(2)(-/-) mice). Mean arterial pressure (MAP) was measured via a ca...

The biologic activity of human biosynthetic granulocyte-monocyte colony stimulating factor (GM-CSF) was investigated in serum-free culture of erythroid progenitors derived from adult peripheral blood. The morphology of erythroid bursts and the cloning efficiency of BFU-E under serum-free conditions were similar to those observed in dishes with fetal bovine serum (FBS). For these experiments, pr...

(Ep) production was studied in control and nephrectomized sheep fetuses beginning at about 100 d of gestation. Fetuises were given injections of either 1.2 mg/d x 13 of L-T4, 12 mg, once every 5 d x 3 of DT or the vehicle alone. Fetal plasma samples for Ep determinations were obtained before and at intervals after the start of the treatment. Retictulocyte and hematocrit levels, and the percent ...

While some researchers have questioned the efficacy of corrective feedback (CF), other researchers believe that CF can be effective if implemented through new technology types, including e-portfolio (EP). However, whether EP can be used as a medium of providing CF for language learners at different levels of language proficiency is still unknown. The purpose of the present study, therefore, was...

Ectopic pregnancy (EP) remains a considerable cause of morbidity and occasional mortality. Currently, there is no reliable test to differentiate ectopic from intrauterine gestation. We have previously used array technology to demonstrate that differences in gene expression in decidualized endometrium from women with ectopic and intrauterine gestations could be used to identify candidate diagnos...

The bioethanol is playing an increasingly important role in renewable energy in China. Based on the theory of circular economy, integration of different resources by polygeneration is one of the solutions to improve energy efficiency and to reduce environmental impact. In this study, three modes of bioethanol production were selected to evaluate the life cycle energy efficiency and environmenta...

Multifunctional self-healing composites have great potential in several applications, i.e., from automotive to aerospace. This study examines the behavior of carbon fiber reinforced by depositing jet-spun cyclic olefin copolymer (COC) meshes on dry plies before lamination with epoxy resin (EP). Three different laminates were prepared, including neat EP/CF and two 4 wt.% 8 COC form a network as ...

PGE(2) is a potent stimulator of renin release. So far, the contribution of each of the four PGE(2) receptor subtypes (EP(1)-EP(4)) in the regulation of renin release has not been characterized. Therefore, we investigated the effects PGE(2) on renin secretion rates (RSR) from isolated, perfused kidneys of EP(1)-/-, EP(2)-/-, EP(3)-/-, EP(4)-/-, and wild-type mice. PGE(2) concentration dependent...

Entropy production (EP) is a key quantity in thermodynamics, and yet measuring EP has remained challenging task. Here we introduce an estimator, called multidimensional entropic bound (MEB), utilizing ensemble of trajectories. The MEB can accurately estimate the overdamped Langevin systems with arbitrary time-dependent protocol. Moreover, it provides unified platform to underdamped under certai...