This paper presents a new 4-degree-of-freedom parallel mechanism dedicated to handling of heavy parts within a large workspace. These 4 degrees of freedom are 3 translations and 1 rotation about a given axis. Such a mechanism is rare; most of common parallel mechanisms have 3 or 6 degrees of freedom. Firstly, a description of the mechanism is given. Then models are derived regarding velocity an...

Phosphatidylinositol (PI) 3-kinase plays an important role in the signalling of cell growth. We previously purified two types of PI 3-kinase from bovine thymus, a monomer from (PI 3-kinase I) and a heterodimer form (PI 3-kinase II) [Shibasaki, Homma and Takenawa (1991) J. Biol. Chem. 266, 8108-8114]. Here we examine the properties of these purified PI 3-kinases. Both PI 3-kinases were inhibited...

For any compact Riemannian surface of genus three $(\Sigma, ds^2)$ Yang and Yau proved that the product first eigenvalue Laplacian $\lambda_1(ds^2)$ area $Area(ds^2)$ is bounded above by $24\pi$. In this paper we improve result show $\lambda_1(ds^2) Area(ds^2) \leq 16(4 - \sqrt{7})\hspace{.02cm}\pi \approx 21.668\hspace{.02cm}\pi$. About sharpness bound, for hyperbolic Klein quartic numerical c...

We have investigated the nongenomic as well as the genomic effects of glucocorticoids on phosphate (Pi) uptake in primary rabbit renal proximal tubule cells (PTCs) and have defined the involved signaling pathways. In the present study, cortisol-BSA (cortisol-BSA) (>10(-9) M, 30 min) was found to inhibit Pi uptake in a time- and concentration-dependent manner. However, progesterone-BSA (P(4)-BSA...

We obtain q-analogues of several series for powers $$\pi $$ . For example, the identity $$\begin{aligned} \mathop {\sum }\limits _{k=0}^\infty \frac{(-1)^k}{(2k+1)^3}=\frac{\pi ^3}{32} \end{aligned}$$ has following q-analogue: (-1)^k\frac{q^{2k}(1+q^{2k+1})}{(1-q^{2k+1})^3}=\frac{(q^2;q^4)_{\infty }^2(q^4;q^4)_{\infty }^6}{(q;q^2)_{\infty }^4}, where q is any complex number with $$|q|<1$$ al...

We examine the axion emission from supernovae with a complete set of relevant couplings including axion-pion-nucleon contact interaction which was ignored in previous studies. Two processes are affected by interaction, $\pi^-+p \rightarrow n + a$ and $n+p\rightarrow n+p+a$, these can be dominant source axions for some region parameter space or astrophysical conditions encountered inside superno...

This review focuses on indeterminate lesions on prostate magnetic resonance imaging (MRI), assigned as PI-RADS category 3. The prevalence of PI-RADS 3 index lesion in the diagnostic work-up is significant, varying between one in three (32%) to one in five (22%) men, depending on patient cohort of first biopsies, previously negative biopsies, and active surveillance biopsies. A management strate...

Simple, straightforward and optimized procedures for preparing extended pi-conjugated linkers are described. Either unsubstituted or 4-donor substituted pi-linkers bearing a styryl, biphenyl, phenylethenylphenyl, and phenylethynylphenyl pi-conjugated backbone are functionalized with boronic pinacol esters as well as with terminal acetylene moieties allowing their further use as building blocks ...