Spontaneously hypertensive rats are less susceptible than normotensive rats to disruption of the blood-brain barrier during acute hypertension. The purpose of this study was to examine mechanisms that protect the blood-brain barrier from disruption in chronically hypertensive rats during acute hypertension. Normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (S...

These studies were designed to investigate the relationship between cerebral prostanoid synthesis and pial arterial caliber in chloralose-anesthetized newborn pigs with normal blood gases and pH and during combined arterial hypoxia and hypercapnia. Piglets less than 5 days old were equipped with closed cranial windows to allow direct observation of pial vessels, application of prostaglandin E2,...

SHAPIRO, HARVEY M., DON D. STROMBERG, DENNIS R. LEE, AND CURT A. WIEDERHIELM. Dynamic pressures in the pial arterial microcirculation. Am. J. Physiol. 22 l(1) : 279-283. 197 1 .-Using a modified Wiederhielm servo-micropipet system with pipet tips of 0.5-l p diam, we measured and recorded dynamic arterial pressures in 42 arteries and arterioles of the pial vascular network on the surface of the ...

Background and Importance: Intracranial pial arteriovenous fistula is a recently described matter as a rare vascular malformation occurring in children. It is usually located in the subpial space in the intracranial cavity with a high-flow shunt. Case Presentation: Authors report on a 2-year-old child with intracranial pial arteriovenous fistula and progressive enlargement of he...

Background Endometrial receptivity is one of parameters which determine the reproductive outcome in in vitro fertilization programs. A good blood supply towards the endometrium is usually considered to be an essential requirement for implantation. Blood vessels of the endometrium can be detected by transvaginal color and pulse Doppler sonography. Color Doppler assessment permits better visualiz...

Pial arterioles of mice were suffused in situ with terf-butyl hydroperoxide (TBHP). This agent has been reported to stimulate synthesis or release of the constrictor, thromboxane. In the present study we observed pial arterioles by in vivo microscopy. Locally applied TBHP produced dose-dependent constriction, significantly inhibited by each of three drugs: acet visa] icy lie acid, OKY-046, and ...

BACKGROUND AND PURPOSE Substantial evidence now implicates endothelin (ET) in the pathophysiology of cerebrovascular disorders such as the delayed vasospasm associated with subarachnoid hemorrhage and ischemic stroke. We investigated the ET receptor subtypes mediating vasoconstriction in human pial arteries. METHODS ET receptors on human pial and intracerebral arteries were visualized with th...

7 The execution and maintenance of all brain functions are dependent on a continuous flow of 8 blood to meet the metabolic needs of the tissue. To ensure the delivery of resources required for neural 9 processing and the maintenance of neural homeostasis, the cerebral vasculature is elaborately and 10 extensively regulated by signaling from neurons, glia, interneurons, and perivascular nerves. ...

background: aneurysm is a blood-filled bulge in the wall of vessels that occurred in abdominal aortic and cerebral vessels. the dilation of artery leads to aneurysm. methods: three dimensional modelling was utilized for a patient with cerebral aneurysm and a normal subject, and additional fluid-structural interaction simulation was performed. we consider pulsatile blood velocity as inlet, and b...