Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied. We used MARCO-deficient mice to directly test the in vivo role of AM MARCO in innate defense against pneumococcal infection and environmental particles. In a murine model ...

The SemanticWeb envisions a World Wide Web in which data is described with rich semantics and applications can pose complex queries. To this point, researchers have defined new languages for specifying meanings for concepts and developed techniques for reasoning about them, using RDF as the data model. To flourish, the Semantic Web needs to provide interoperability -both between sites with diff...

Andrea Bosin1, Nicoletta Dessì, Maria Grazia Fugini2, Diego Liberati, Barbara Pes1 1 Università degli Studi di Cagliari, Dipartimento di Matematica e Informatica, Via Ospedale 72, 09124 Cagliari [email protected], {dessi,pes}@unica.it 2 Politecnico di Milano, Dipartimento di Elettronica e Informazione, Piazza da Vinci 32, I-20133 MILANO [email protected] 3 IEIIT CNR c/o Politecnico ...

The empirical relevance of indeterminacy and sunspot fluctuations has been often questioned on the basis of the implausibly high degrees of increasing returns to scale or unconventional calibrations for the fundamentals required. In this paper we study a one-sector economy with partial cash-in-advance constraint on consumption expenditures, and show how such phenomena are by contrast quite perv...

Background The ligation of the patent processus vaginalis (PPV) is the challenging issue during the orchidopexy in the patients who suffering undescended testis (UDT). In the present study we aimed to comparing the advantages of the orchidopexy with high-ligation method and the san-ligation method as a modified orchidopexy in our more than 6 years` experiences. Materials and Methods The medical...

The scavenger receptor MARCO mediates macrophage recognition and clearance of pathogens and their polyanionic ligands. However, recent studies demonstrate MARCO expression and function in dendritic cells, suggesting MARCO might serve to bridge innate and adaptive immunity. To gain additional insight into the role of MARCO in dendritic cell activation and function, we profiled transcriptomes of ...

pathway: new chemical entities targeting selectively the CD14 and MD-2 receptors Francesco Peri,1 Matteo Piazza,1 Gaetana Damore,1 Valentina Calabrese,1 Roberto Cighetti,1 Theresa Gioannini,2 Jerrold Weiss2 1Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza, 2; Milano, Italy; E-mail: [email protected]; 2 Inflammation Program/Veterans’ Adminis...