Background/aims: It is well known that light skin pigmentation is a risk factor for cutaneous melanoma. The aim of this study was to investigate the analogous association between choroidal pigmentation and posterior uveal melanoma. Methods: Cross sectional study of 65 consecutive patients diagnosed with posterior uveal melanoma (melanoma group) and 218 consecutive patients referred for general ...

BACKGROUND Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not available. OBJECTIVE The primary obj...

The mechanistic Target of Rapamycin Complex 1 (mTORC1) regulates multiple physiological functions, ranging from nutrient sensing and metabolism to proliferation senescence. In cell culture, mTORC1 inhibition can promote pigmentation, while its role in human hair follicle (HF) biology remains unknown. Since patients with a loss-of-function mutation the key endogenous inhibitor activity, tuberous...